PMID: 8597884Nov 1, 1995Paper

Effect of cyclophosphamide on lymphokine production in MRL/lpr.Yaa mice

Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]
H KamadaH Nagai

Abstract

The Y chromosome (Yaa gene) from autoimmune BXSB mice has been shown to be responsible for the acceleration of autoimmune symptoms when transferred to MRL/lpr mice. We examined the pathological, serological and immunological characteristics of MRL/lpr. Yaa mice and the suppressive effect of cyclophosphamide (CP) on the mice. MRL/lpr. Yaa mice spontaneously developed a massive lymphadenopathy characterized by hypergammaglobulinemia, the presence of several autoantibodies, and autoimmune disease. In MRL/lpr. Yaa mice, IL-2, IL-4 and IL-5 production in concanavalin A (Con A)-stimulated splenocytes were about 10-fold lower than in BALB/c mice at 5 weeks of age. The concentrations of these lymphokines remained low until the mice were 16 weeks of age. The production of IFN-gamma and IL-6 in 16 week old MRL/lpr. Yaa mice was about 4- and 2-fold lower, respectively, though these levels were similar in both strains at 8 weeks of age. It was found that this dysregulation of T cell function was almost identical to that in MRL/lpr mice. Administration of CP to MRL/lpr. Yaa mice ameliorated nephritis, and suppressed production of autoantibodies and the accumulation of abnormal T cells. CP also significantly elevated the production of lympho...Continue Reading

References

Nov 1, 1978·The Journal of Experimental Medicine·B S AndrewsF J Dixon
Jan 1, 1990·European Journal of Immunology·L J MurrayC Martens
Jul 1, 1989·Molecular Immunology·S UmlandC Martens
Feb 1, 1985·The Journal of Experimental Medicine·L M HangA N Theofilopoulos
Nov 1, 1981·The Journal of Experimental Medicine·D WofsyN Talal
Jun 1, 1982·The Journal of Experimental Medicine·L HangF J Dixon

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Citations

Sep 10, 2014·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Harold V Parks, James E Faller

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