Effect of cyclosporin A, azathioprine, and prednisolone on carbohydrate metabolism of rat hepatocytes

Transplant International : Official Journal of the European Society for Organ Transplantation
W RiegelW H Hörl


The effect of different immunosuppressive drugs (prednisolone, azathioprine, cyclosporin A) on liver carbohydrate metabolism in the rat was investigated. Daily administration of prednisolone (3 mg/kg body weight) and azathioprine (2 mg/kg body weight) intraperitoneally for 2 weeks caused significantly lower liver glycogen content than that in NaCl-treated controls. Liver glucose and lactate content, as well as plasma glucose, glucagon, and serum insulin concentration of these animals, remained unchanged. There were no differences in any of these parameters between cyclosporin A (15 mg/kg body weight)-treated and vehicle (olive oil/ethanol)-treated animals. Prednisolone caused significantly lower glucose production in isolated rat hepatocytes using Na-pyruvate as the substrate, whereas glucose production was unchanged in hepatocytes of azathioprine-treated rats using pyruvate or L-serine as substrates. Glucose production from pyruvate or serine was significantly inhibited by cyclosporin A compared to the vehicle, but did not differ from the effects of azathioprine and prednisolone. Lactate production was significantly lower in cyclosporin-treated animals than in those given either the vehicle or azathioprine. Cyclosporin A compl...Continue Reading


Jan 1, 1975·Annals of Internal Medicine·P S Schein, S H Winokur
Sep 1, 1989·Klinische Wochenschrift·W H HörlH Wilms
Apr 1, 1989·Transplant International : Official Journal of the European Society for Organ Transplantation·W RiegelW H Hörl
Jun 1, 1988·Transplantation·P J GarvinJ Staggenborg
Jan 1, 1985·American Journal of Nephrology·E A FriedmanK M Butt
Dec 1, 1985·Diabetes·J F YaleE B Marliss
Dec 1, 1967·Archives of Internal Medicine·E L KrawittJ A Clifton
Oct 1, 1972·Metabolism: Clinical and Experimental·J H Exton
Apr 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·S M TilghmanF J Ballard
Apr 1, 1980·Transplantation·M G McGeownC M Hill

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