PMID: 6968408Oct 9, 1980Paper

Effect of cyclosporin A on T-dependent and T-independent immunoglobulin synthesis in vitro

Nature
T Paavonen, P Häyry

Abstract

An immunosuppressive cyclic polypeptide, cyclosporin A (CyA), isolated originally from two species of fungi, prolongs organ allograft survival in several species. However, virtually nothing is known about the pharmacokinetics of this substance and its mode of action in man. We have quantified the impact of CyA on T-dependent and T-independent immunoglobulin (Ig) synthesis of human blood leukocytes in vitro, and on the proliferating capacity of the interacting lymphoid cell populations--T cells, B cells, T mu and T gamma cells. CyA inhibited all responses at approximately equal concentrations. The blast cells rather than resting lymphocytes and/or Ig-synthesizing plasma cells were incapacitated by the drug. As the phagocytosis of accessory macrophages was inhibited only at a 100--1,000-fold higher drug concentration, we conclude that CyA has a relatively specific direct effect on human T and B blast cells in vitro.

References

Jul 1, 1976·Agents and Actions·J F BorelH Stähelin
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Jun 1, 1976·Scandinavian Journal of Immunology·P Häyry, L C Andersson
Mar 1, 1976·European Journal of Immunology·A ForsgrenH Wigzell

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Citations

Aug 1, 1994·Transplant International : Official Journal of the European Society for Organ Transplantation·J H StarkB Gridelli
Oct 1, 1984·Agents and Actions·A W ThomsonJ G Simpson
Jan 1, 1984·International Journal of Immunopharmacology·N W BrattigP A Berg
Jan 1, 1990·International Journal of Immunopharmacology·S SozzaniA Vecchi
Sep 1, 1983·The Journal of Experimental Medicine·A MuraguchiA S Fauci
Feb 1, 1990·Clinical and Experimental Immunology·N SuzukiT Tsunematsu
Aug 1, 1990·Immunobiology·G KolbH Lange
Nov 20, 2009·Clinical and Experimental Immunology·S HeidtA Mulder
Mar 1, 1983·Scandinavian Journal of Immunology·R BergerW Knapp
Jan 1, 1980·Scandinavian Journal of Immunology·A Nemlander, P Häyry
Jan 1, 1982·Immunological Reviews·S Britton, R Palacios
May 1, 1981·Immunology Today·G G Klaus
Oct 6, 2018·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Yoon Hong ChunKyung-Sun Na
May 1, 1981·Scandinavian Journal of Immunology·L Andrus, K J Lafferty
Aug 4, 1986·The Medical Journal of Australia·P J Miach
Aug 18, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Matthew B Roberts, Jay A Fishman

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