Effect of cyclosporin A treatment on the production of antibody in insulin-dependent (type I) diabetic patients

The Journal of Clinical Investigation
C BoitardJ F Bach

Abstract

Anti-islet cell and anti-insulin antibody production was studies over a 12-mo period in 82 recently diagnosed diabetics randomly receiving either cyclosporin or placebo. Cyclosporin had only minimal effects on the production of anti-islet cell antibodies whether directed to islet cytoplasmic (immunofluorescence) or membrane (cytotoxicity assay) antigens even in patients undergoing remission. These data suggest that these antibodies do not play a major role in the pathogenesis of the disease particularly since their (irregular) presence is not predictive of the clinical response to cyclosporin. Conversely, cyclosporin completely suppressed the synthesis of antibodies elicited by exogenous insulin irrespective of the insulin doses received, and decreased the autoantibody production against thyroid antigens, indicating that cyclosporin has variable effects on antibody production against various antigens.

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Apr 1, 1994·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·S EpsteinW S Jee
Sep 1, 1996·Diabetologia·T Mandrup-Poulsen
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Related Concepts

Antibody Formation
Autoantibodies
Clinical Trials
Cyclosporins
Immunologic Tumoricidal Activities
Diabetes, Autoimmune
Novolin
Islets of Langerhans
Placebos
Randomization

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