PMID: 7819002Oct 1, 1994Paper

Effect of cyclosporine A on long-term allograft function in pediatric renal transplant recipients

Pediatric Nephrology : Journal of the International Pediatric Nephrology Association
A W WilliamsD S Milliner

Abstract

There have been concerns regarding long-term adverse effects of cyclosporine A (CSA) on renal allograft function. In a retrospective study, we compared long-term allograft function up to 70 months after renal transplantation in pediatric recipients treated with and without CSA, using iothalamate clearance to assess glomerular filtration rate. Patients received CSA, prednisone, and azathioprine (CSA group, n = 16) or prednisone and azathioprine alone (Pred/AZA, n = 11). At 48 months post transplant, the iothalamate clearances (mean +/- SD) were 57.9 +/- 26.8 ml/min per 1.73 m2 in the CSA group and 68.5 +/- 20.2 in the Pred/AZA group (P > 0.05). The mean of the slopes of individual iothalamate clearances versus time during the first 70 months following transplantation were -0.156 in the CSA group and 0.095 in the Pred/AZA group. Neither slope was statistically different from zero. These data suggest that allograft function is not significantly depressed by CSA at 48 months post transplantation and that there is no greater rate of decline in allograft function up to 70 months post transplantation in patients receiving CSA when compared with the AZA/Pred group.

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Citations

Dec 7, 2002·Diabetes/metabolism Research and Reviews·Roger AssanJean-François Bach
Apr 30, 1999·Transplantation·E QvistC Holmberg
Dec 16, 2004·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Rulan S Parekh, Samuel S Gidding
Aug 29, 2006·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Jodi M SmithFrank A Roberts
Nov 23, 2006·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Mark M Mitsnefes
Sep 17, 2013·Clinical Transplantation·Misbah A MotenSamir J Patel
Jan 17, 2019·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Mads HornumAllan Rasmussen
Feb 13, 2003·Pediatric Transplantation·Douglas M Silverstein
Jul 22, 2004·Pediatric Transplantation·Douglas M Silverstein
Oct 4, 2007·Pediatric Transplantation·Douglas M SilversteinJ Philip Boudreaux
Apr 4, 2017·Pediatric Transplantation·Sandra HabbigLutz T Weber

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