Effect of Cydonia oblonga Mill. leaf extract on serum lipids and liver function in a rat model of hyperlipidaemia

Journal of Ethnopharmacology
Ablat AblizAnwar Umar

Abstract

Cydonia oblonga Mill. leaves are traditionally used in Uyghur medicine to treat or prevent cardiovascular disease. Beyond a demonstrated effect on thrombosis, we tested it for an effect on dyslipidemia, in a rat model of hyperlipidemia. Seventy healthy Sprague Dawley rats were randomly divided into 6 groups: normal controls, model controls, simvastatin, and low-, medium- and high-dose Cydonia oblonga Mill. leaf extracts (COM), orally for 56 days. The normal controls were fed a normal diet, all other groups a high fat diet. Rat weights were recorded over time. Total cholesterol (TC), triglycerides (TG), low and high-density lipoproteins (LDL, HDL), as well as AST, ALT and total protein (TP) were measured in serum at the end of the study. The antioxidant capacity of glutathione peroxidase (GSH-PX), superoxide dismutase (SOD), malondialdehyde (MDA) was measured in liver samples, along with lipoprotein lipase (LPL), and hepatic lipase (HL). Liver pathology was described. COM dose-dependently reduced TC, TG, LDL-C and MDA, inhibited the activity of ALT, AST and LPS, increased HDL-C content, increased the activity of SOD, GSH-PX, LPL and HL, and reduced liver steatosis in hyperlipidaemia rats, which was significant at medium and high...Continue Reading

References

Oct 1, 2008·Progress in Lipid Research·Giovanni MussoMaurizio Cassader
Mar 2, 2010·Biological & Pharmaceutical Bulletin·Yi-Seong KwakMan-Hee Rhee
Nov 3, 2010·Digestion·Alexander WreeAli Canbay
Jan 25, 2011·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Carsten GründemannRoman Huber

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Citations

Jul 26, 2016·Frontiers in Pharmacology·Muhammad U AshrafSyed N A Bukhari
Jun 15, 2016·British Journal of Clinical Pharmacology·Nicholas MooreAnwar Umar
Jun 26, 2017·Journal of Ethnopharmacology·Yuanheng GuoBing Zhao
Feb 9, 2017·International Journal of Biological Macromolecules·Lijun ZhangBing Zhao
Apr 4, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Peipei ZhouFei Li
May 16, 2019·Fish Physiology and Biochemistry·Erika do Carmo OtaClaudia Andrea Lima Cardoso
May 13, 2020·Redox Report : Communications in Free Radical Research·Abdulaziz M S AlSaadSalim S Al-Rejaie
Jun 2, 2017·Frontiers in Microbiology·Chenyang LuXiurong Su
Nov 4, 2017·Applied Microbiology and Biotechnology·Chenyang LuXiurong Su
Feb 26, 2019·Journal of Medicinal Food·Ju-Hyoung ParkJoa Sub Oh
Aug 14, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Bachir Benarba, Atanasio Pandiella

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