PMID: 3746287Jan 1, 1986Paper

Effect of cytidine(5')diphosphocholine (CDP-choline) on the total urinary excretion of 3-methoxy-4-hydroxyphenylglycol (MHPG) by rats and humans

Journal of Neural Transmission
I LopezR J Wurtman

Abstract

We examined the effects of orally administered cytidine(5')-diphosphocholine (CDP-choline) on the total levels of 3-methoxy-4-hydroxyphenylglycol (MHPG) in human and rat urine. Four subjects who had been on a low-choline diet (less than 1 gm/day) for 24 hours received three doses of CDP-choline (2 gm each) at 8 a.m., 10 a.m., and noon; urines were collected at two-hour intervals after each dose. Rats received water for three days; then CDP-choline (100 mg/kg) or equimolar doses of choline for five days; then water again for three more days. Twenty-four hour urine samples were collected on each day of the study. The levels of MHPG in human urine increased by 45-68% when subjects were receiving CDP-choline (p less than 0.01). CDP-choline, but not choline, also elevated urinary MHPG significantly in rats (p less than 0.01). These data suggest that CDP-choline enhances norepinephrine release, and that this action may be mediated by more than just its choline content.

References

Feb 15, 1974·Experientia·S ManakaH Sekino
Nov 1, 1980·Neurology·S H ZeiselM Logue
Oct 1, 1980·Archives of General Psychiatry·P A BlomberyM H Ebert
Jan 1, 1980·Journal of Neural Transmission·R AlonsoR J Wurtman

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Citations

Jun 1, 1992·The Journal of Nutritional Biochemistry·I López G-CoviellaR J Wurtman
Oct 6, 2000·Clinical Biochemistry·C PlatarasP Angelogianni
May 26, 1998·European Journal of Pharmacology·R Giménez, J Aguilar
Mar 5, 2009·The International Journal of Eating Disorders·William D S KillgoreDeborah A Yurgelun-Todd
Mar 9, 2010·Journal of the International Society of Sports Nutrition·Shona S CraigSteven H Zeisel
Mar 1, 1990·British Journal of Industrial Medicine·R R O'Flynn, H A Waldron

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