Effect of cytokines on Japanese encephalitis virus production by human monocytes

Microbiology and Immunology
H HasegawaY Kobayashi

Abstract

Japanese encephalitis (JE) virus was shown to grow in in vitro cultures of human monocytes. Interferon (IFN)-alpha and IFN-gamma inhibited JE virus production by the infected monocytes in the absence of anti-JE virus antibody, but interleukin (IL)-1 alpha, IL-2, IL-3, granulocyte-macrophage colony-stimulating factor (GM-CSF), granulocyte-CSF (G-CSF), and tumor necrosis factor (TNF)-alpha did not show a significant inhibition. Antibody against JE virus increased the JE virus production by the infected monocytes probably by enhanced uptake of virus-antibody complexes via Fc receptors. IFN-gamma and GM-CSF increased JE virus production by monocytes in the presence of anti-JE virus antibody, whereas IFN-alpha inhibited JE virus production even in the presence of the antibody. The other 5 cytokines (IL-1 alpha, IL-2, IL-3, G-CSF, and TNF-alpha) did not show a significant effect on JE virus production by monocytes in the presence or absence of the antibody.

References

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Citations

Oct 30, 2016·Microbiology and Immunology·Takafumi TasakiTsutomu Takegami
Jun 25, 2009·Revista Do Instituto De Medicina Tropical De São Paulo·Veridiana Ester Dias BarrosLuiz Tadeu Moraes Figueiredo
Aug 16, 2017·Journal of Neuroinflammation·Nils LannesLuis Filgueira

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