Effect of D-sorbitol on the thermal gelation of methylcellulose formulations for drug delivery

Chemical & Pharmaceutical Bulletin
Kunihiko ItohDavid Attwood

Abstract

The aim of this study was to examine the effect of D-sorbitol on the gelation characteristics of methylcellulose in aqueous solution. The addition of D-sorbitol at concentrations of between 25 and 30% (w/v) to 1.0-2.0% (w/v) methylcellulose solutions reduced the gelation temperature from approximately 53 degrees Celsius to values between ambient and 37 degrees Celsius and increased the strength of the gel. The in vitro release of acetaminophen (paracetamol) from 2.0% (w/v) methylcellulose gels containing 20-30% (w/v) D-sorbitol gel was diffusion-controlled.

References

Oct 1, 1984·Chemical & Pharmaceutical Bulletin·S MiyazakiM Takada
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Jul 14, 2004·Langmuir : the ACS Journal of Surfaces and Colloids·Yirong XuXiao Hu
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Apr 2, 2009·Drug Development and Industrial Pharmacy·Shozo MiyazakiDavid Attwood

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Citations

Jan 31, 2012·Drug Development and Industrial Pharmacy·Tetsuya ShimoyamaDavid Attwood
Mar 17, 2011·Drug Development and Industrial Pharmacy·Kunihiko ItohDavid Attwood
Nov 22, 2011·Journal of the Science of Food and Agriculture·María José Tavera-QuirozNora Bertola
Jun 4, 2013·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Tetsuya ShimoyamaMichiya Kobayashi
Jul 18, 2017·Bioscience, Biotechnology, and Biochemistry·Yoshiaki ShirataTomihiro Miyada

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