Effect of Daily Antenatal Iron Supplementation on Plasmodium Infection in Kenyan Women: A Randomized Clinical Trial

JAMA : the Journal of the American Medical Association
Martin N MwangiHans Verhoef

Abstract

Anemia affects most pregnant African women and is predominantly due to iron deficiency, but antenatal iron supplementation has uncertain health benefits and can increase the malaria burden. To measure the effect of antenatal iron supplementation on maternal Plasmodium infection risk, maternal iron status, and neonatal outcomes. Randomized placebo-controlled trial conducted October 2011 through April 2013 in a malaria endemic area among 470 rural Kenyan women aged 15 to 45 years with singleton pregnancies, gestational age of 13 to 23 weeks, and hemoglobin concentration of 9 g/dL or greater. All women received 5.7 mg iron/day through flour fortification during intervention, and usual intermittent preventive treatment against malaria was given. Supervised daily supplementation with 60 mg of elemental iron (as ferrous fumarate, n = 237 women) or placebo (n = 233) from randomization until 1 month postpartum. Primary outcome was maternal Plasmodium infection at birth. Predefined secondary outcomes were birth weight and gestational age at delivery, intrauterine growth, and maternal and infant iron status at 1 month after birth. Among the 470 participating women, 40 women (22 iron, 18 placebo) were lost to follow-up or excluded at birt...Continue Reading

Associated Clinical Trials

Citations

May 1, 2016·Jornal de pediatria·Alida Melse-Boonstra, Martin Ndegwa Mwangi
Sep 21, 2016·BMC Medicine·Holger W UngerStephen J Rogerson
Mar 9, 2017·British Journal of Haematology·Martin N MwangiHans Verhoef
Oct 19, 2019·European Journal of Clinical Nutrition·Ajibola I AbioyeWafaie Fawzi
Jul 18, 2020·The Cochrane Database of Systematic Reviews·Martha S FieldJuan Pablo Peña-Rosas
Jun 8, 2017·Nutrients·Martin N MwangiAndrew M Prentice
Jul 24, 2018·Nutrition Research Reviews·Martin N MwangiJoop J A van Loon
Aug 20, 2019·PLoS Neglected Tropical Diseases·Inge KroidlChristof Geldmacher
Jan 1, 2016·Hematology
May 16, 2019·Annual Review of Nutrition·Michael K GeorgieffSarah E Cusick
Dec 8, 2020·Lancet·Sant-Rayn PasrichaDorine W Swinkels
Jan 19, 2021·The Cochrane Database of Systematic Reviews·Martha S FieldJuan Pablo Peña-Rosas
Apr 15, 2019·Seminars in Perinatology·Minghua Tang, Nancy F Krebs
Feb 6, 2018·The Lancet Infectious Diseases·Stephen J RogersonAnna M van Eijk
Aug 28, 2021·Frontiers in Nutrition·Dorothy K MuruguChrysantus M Tanga
Apr 11, 2019·Acta Haematologica·Thomas G DeLoughery

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