Effect of dairy products on initiation of precursor lesions of colon cancer in rats

Nutrition and Cancer
H AbdelaliJ F Narbonne

Abstract

This study reports the modulating effect of some dairy products on initiation of putative preneoplasic lesions in rat colon (aberrant crypts) by 1,2-dimethylhydrazine dihydrochloride. Uninoculated skim milk, skim milk fermented with Bifidobacterium sp Bio (Danone strain 173010), and a suspension of the same lactic acid bacteria were incorporated in the animals' diet. The tested diets significantly reduced the incidence of aberrant crypts compared with the control diet by 51%, 49%, and 61%, respectively. The effects of the diets on cecal pH, hepatic UDP-glucuronyltransferase activity, and cecal microflora enzyme beta-glucuronidase were also studied. There was no significant difference in cecal pH between rats fed experimental diets and control rat. The diet supplemented with the Bifidobacterium strain suspension significantly decreased only the cecal beta-glucuronidase activity. Both enzyme activities were reduced in rats fed fermented skim milk- or uninoculated skim milk-supplemented diets compared with control animals.

References

Mar 1, 1979·Journal of Agricultural and Food Chemistry·K Yano
Dec 1, 1977·Biulleten' eksperimental'noĭ biologii i meditsiny·I G BogdanovM N Kolosov
Aug 1, 1976·Journal of the National Cancer Institute·B R Goldin, S L Gorbach
Oct 1, 1975·FEBS Letters·I G BogdanovI B Sorokina
Jul 1, 1992·Journal of the National Cancer Institute·X M ZhangM C Archer
Nov 1, 1969·Archives of Biochemistry and Biophysics·J A WittkopD J Reed
May 16, 1981·Lancet·J R Thornton
May 1, 1984·The American Journal of Clinical Nutrition·B R Goldin, S L Gorbach
Jan 1, 1983·Nutrition and Cancer·H P Glauert, M R Bennink
Nov 1, 1993·Mutation Research·W R BruceX M Zhang
Nov 1, 1994·The Journal of Dairy Research·P CassandJ F Narbonne
May 1, 1983·Journal of Food Protection·K M ShahaniP J Bailey

❮ Previous
Next ❯

Citations

Jul 8, 2000·Microbes and Infection·K Hirayama, J Rafter
Apr 18, 2000·Mutation Research·H TsudaM A Moore
Sep 26, 2003·Best Practice & Research. Clinical Gastroenterology·Joseph Rafter
Sep 7, 2002·The British Journal of Nutrition·J Rafter
Dec 1, 2004·Nutrition Research Reviews·Joseph Rafter
Mar 23, 2006·Gastroenterology Nursing : the Official Journal of the Society of Gastroenterology Nurses and Associates·Ilse J Broekaert, W Allan Walker
Apr 25, 2006·Journal of Clinical Gastroenterology·Ilse J Broekaert, W Allan Walker
Jun 11, 2002·Annual Review of Nutrition·Jonathan E Teitelbaum, W Allan Walker
Jun 28, 2011·American Journal of Physiology. Gastrointestinal and Liver Physiology·M Andrea Azcárate-PerilJosé M Bruno-Bárcena
Mar 3, 2007·Biological & Pharmaceutical Bulletin·Eunju ParkHyun-Dong Paik
Nov 26, 2008·World Journal of Gastroenterology : WJG·Constantine-Iosif FotiadisEleftherios-Dimitriou Zografos
Mar 2, 2010·International Journal of Food Sciences and Nutrition·Manoj KumarHariom Yadav
Jan 30, 2007·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Gabriele CapursoGianfranco Delle Fave
Sep 20, 2005·Alimentary Pharmacology & Therapeutics·C PicardC Matuchansky
May 25, 2011·International Journal of Cancer. Journal International Du Cancer·Valeria PalaVittorio Krogh
Apr 6, 2013·Journal of Medical Microbiology·Imen KahouliSatya Prakash
Jun 1, 1997·Japanese Journal of Cancer Research : Gann·K SekineH Tsuda
Oct 1, 2004·Nutrition and Cancer·Joumana SaikaliPeter Holt
Mar 10, 2001·The British Journal of Nutrition·H S Gill, M L Cross
Mar 16, 2002·Carcinogenesis·Emmanuelle TavanPierrette Cassand
May 3, 2005·Molecular Nutrition & Food Research·Chiara C LimGerald W Tannock
Jan 28, 2003·European Journal of Clinical Nutrition·T Norat, E Riboli
Mar 23, 2002·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Hiroyuki TsudaMasaaki Ligo
Jul 12, 2019·Nutrition and Cancer·Jianhua WuYuan Wen Xu
Apr 3, 2003·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·H HorieJ Rafter
Mar 18, 2000·The Journal of Nutrition·L J BradyF F Busta
Jul 8, 1999·The Journal of Nutrition·H VesperA H Merrill
Jul 8, 1999·The Journal of Nutrition·D D Gallaher, J Khil
Jan 22, 2020·Digestive Diseases and Sciences·Poliana Guiomar de Ameida BrasielReggiani Vilela Gonçalves
Jul 3, 2021·Cancers·Ashutosh TripathyManoj Kumar Jena

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.