Effect of dantrolene on KCl- or NMDA-induced intracellular Ca2+ changes and spontaneous Ca2+ oscillation in cultured rat frontal cortical neurons

Journal of Neural Transmission
Takeshi HayashiS Yamawaki

Abstract

Dantrolene has been known to affect intracellular Ca2+ concentration ([Ca2+]i) by inhibiting Ca2+ release from intracellular stores in cultured neurons. We were interested in examining this property of dantrolene in influencing the [Ca2+]i affected by the NMDA receptor ligands, KCl, L-type Ca2+ channel blocker nifedipine, and two other intracellular Ca2(+)-mobilizing agents caffeine and bradykinin. Effect of dantrolene on the spontaneous oscillation of [Ca2+]i was also examined. Dantrolene in microM concentrations dose-dependently inhibited the increase in [Ca2+]i elicited by NMDA and KCl. AP-5, MK-801 (NMDA antagonists), and nifedipine respectively reduced the NMDA and KCl-induced increase in [Ca2+]i. Dantrolene, added to the buffer solution together with the antagonists or nifedipine, caused a further reduction in [Ca2+]i to a degree similar to that seen with dantrolene alone inhibiting the increase in [Ca2+]i caused by NMDA or KCl. At 30 microM, dantrolene partially inhibited caffeine-induced increase in [Ca2+]i whereas it has no effect on the bradykinin-induced change in [Ca2+]i. The spontaneous oscillation of [Ca2+]i in frontal cortical neurons was reduced both in amplitude and in base line concentration in the presence of...Continue Reading

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Citations

Jan 10, 2002·Journal of Neuroscience Research·Noritaka NakamichiYukio Yoneda
Mar 5, 1997·European Journal of Pharmacology·C C ChienG W Pasternak
May 14, 2003·Neurochemistry International·Dorota MakarewiczJerzy W Łazarewicz
Mar 30, 2011·Proceedings of the National Academy of Sciences of the United States of America·Sheel C DodaniChristopher J Chang
Apr 15, 2010·Journal of Lipid Research·Epolia RamadanMireille Basselin
Mar 26, 2010·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·R Scott DuncanPeter Koulen
Jan 15, 2008·Neuroscience Letters·Elzbieta SalinskaJerzy W Lazarewicz
May 20, 2015·Neuroscience Research·Aya KawaguchiYoshiyuki Shibukawa
Aug 2, 2002·Clinical Neuropharmacology·Ronald J Gurrera
Apr 3, 2002·The Journal of Biological Chemistry·Anna FilipekJacek Kuznicki

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