Effect of Dapagliflozin on Insulin Secretion and Insulin Sensitivity in Patients with Prediabetes.

Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association
Alejandra M Ramírez-RodríguezEsperanza Martínez-Abundis

Abstract

To evaluate the effect of dapagliflozin on insulin secretion and insulin sensitivity in patients with prediabetes. A randomized, double-blind, placebo-controlled clinical trial was carried out in 24 adults diagnosed with prediabetes and without pharmacological treatment. Patients were randomly assigned into two groups of 12 patients each to receive 10 mg of oral dapagliflozin or placebo once a day during 12 weeks. At baseline and at the end of the study, anthropometric and metabolic measurements were evaluated, including the first phase of insulin secretion, total insulin secretion, and insulin sensitivity. After dapagliflozin administration, there were significant decreases in body weight (80.8±16.3 vs. 77.8±14.9 kg, p=0.019), body mass index (30.3±3.5 vs. 29.2±3.1 kg/m2, p=0.023), waist circumference (100.6±13.5 vs. 96.2±11.8 cm, p=0.003), fasting glucose (5.9±0.4 vs. 5.1±0.3 mmol/L, p<0.001) and uric acid (334.3±70.8 vs. 262.9±60.7 mmol/L, p=0.032), with a tendency to increase the insulin sensitivity (1.94±0.72 vs. 2.63±1.04, p=0.064). Dapagliflozin administration in patients with prediabetes decreased body weight, body mass index, waist circumference, fasting glucose, and uric acid, with a tendency to increase the insulin s...Continue Reading

Citations

Sep 8, 2020·Expert Opinion on Pharmacotherapy·Marc Rendell
Feb 1, 2019·Drugs·Maria J Pereira, Jan W Eriksson
Apr 17, 2020·Diabetes Therapy : Research, Treatment and Education of Diabetes and Related Disorders·David M WilliamsMarc Evans
Jun 8, 2021·The Journal of Clinical Endocrinology and Metabolism·Karen E Elkind-HirschDrake Bellanger
Sep 21, 2021·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·John WongKenneth Lo
Oct 27, 2021·Endocrine Reviews·Angeliki M AngelidiChristos S Mantzoros

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