Effect of Dapagliflozin With and Without Acipimox on Insulin Sensitivity and Insulin Secretion in T2DM Males.

The Journal of Clinical Endocrinology and Metabolism
Aurora MerovciRalph A DeFronzo

Abstract

To investigate the effect of lowering the plasma glucose and free fatty acid (FFA) concentrations with dapagliflozin and acipimox, respectively, on insulin sensitivity and insulin secretion in T2DM individuals. Fourteen male T2DM patients received an oral glucose tolerance test and euglycemic hyperinsulinemic clamp at baseline and were treated for 3 weeks with dapagliflozin (10 mg per day). During week 3, acipimox (250 mg four times per day) treatment was added to dapagliflozin. The oral glucose tolerance test and insulin clamp were repeated at the end of weeks 2 and 3. Dapagliflozin caused glucosuria and significantly lowered the plasma glucose concentration (by 35 mg/dL; P < .01), whereas the fasting plasma FFA concentration was unaffected. Acipimox caused a further decrease in the fasting plasma glucose concentration (by 20 mg/dL; P < .01) and a significant decrease in the fasting plasma FFA concentration. Compared to baseline, insulin-mediated glucose disposal increased significantly at week 2 (from 4.48 ± 0.50 to 5.30 ± 0.50 mg/kg · min; P < .05). However, insulin-mediated glucose disposal at week 3 (after the addition of acipimox) did not differ significantly from that at week 2. Glucose-stimulated insulin secretion at we...Continue Reading

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Citations

Jun 8, 2017·Expert Opinion on Investigational Drugs·Kalliopi PafiliNikolaos Papanas
Dec 13, 2016·Nature Reviews. Nephrology·Ralph A DeFronzoMuhammad Abdul-Ghani
Dec 22, 2017·Journal of the Endocrine Society·Yasir S ElhassanGareth G Lavery
Jan 25, 2020·Journal of Biochemical and Molecular Toxicology·Noha M GamilNihad I Eid
Sep 6, 2018·Therapeutic Advances in Endocrinology and Metabolism·Gautam DasHussam Abusahmin
Dec 16, 2020·Archives of Endocrinology and Metabolism·Valeria Bahdur Chueire, Elza Muscelli

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