PMID: 11911249Mar 26, 2002Paper

Effect of daunomycin on expression of CD44H protein in HTB140 melanoma cells in vitro

Anticancer Research
J DrukalaZ Pietrzkowski

Abstract

CD44H is a transmembrane protein involved in cell-cell and cell-matrix interactions. In melanoma cells CD44H influences motility and invasiveness. Daunomycin (daunorubicin) is an anthracycline antibiotic, capable to inducing apoptosis in many cell lines. The data presented in this report show that 12-hours treatment with clinically applied concentration of daunomycin led to apoptotic death of a portion of the investigated melanoma cell population. Surviving cells showed random distribution of CD44H and decreased expression of the protein on the cell surface, but no cell blebbing or changes in nuclei. Hypothetical mechanisms concerning a role of CD44H in induction of apoptosis are discussed.

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Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis