Effect of dazoxiben on arterial graft thrombosis in the baboon

British Journal of Clinical Pharmacology
S R Hanson, L A Harker

Abstract

1 The thromboxane A2 synthetase inhibitor dazoxiben (UK 37248) was given orally to normal male baboons to determine its effect on platelet function in forming haemostatic plugs, and its capacity to prevent arteriovenous shunt and vascular graft thrombosis. 2 The standard template bleeding time was prolonged significantly at all doses ranging from 10-100 mg/kg (P less than 0.02 in all cases). 3 Doses ranging from 20-100 mg/kg daily did not normalize shortened platelet survival time or increased platelet destruction associated with chronic thrombogenic arteriovenous cannulae (P greater than 0.5). 4 A dose of 50 mg/kg did not reduce the rate or extent of acute platelet deposition on to Dacron vascular grafts (P greater than 0.5). 5 Despite significant inhibition of the platelets' capacity to form haemostatic plugs dazoxiben alone is ineffective in the prevention of prosthesis-related arterial thrombosis in the doses studied.

References

Aug 1, 1979·The Journal of Clinical Investigation·L A Harker, S R Hanson
Aug 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·G J RothP W Majerus
Aug 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·M HambergB Samuelsson
Feb 7, 1974·The New England Journal of Medicine·A KaegiM Gent
Jun 24, 1971·The New England Journal of Medicine·J M SullivanR Gorlin
May 16, 1981·Lancet·J VermylenM Verstraete

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Citations

Feb 1, 1997·Cardiovascular Surgery : Official Journal of the International Society for Cardiovascular Surgery·T E BrothersP V Halushka
Feb 1, 1994·European Journal of Clinical Investigation·C M Kessler, S R Hanson
Jan 1, 1983·Thrombosis Research. Supplement·M J Randall
Apr 1, 1986·The Journal of Surgical Research·E D EndeanJ L Cronenwett
May 20, 1998·American Heart Journal·S R Hanson, K S Sakariassen
Mar 24, 1998·Journal of Vascular Surgery·T E BrothersJ M Boggs
Oct 30, 2008·Thrombosis Journal·Karl MalmBjörn Dahlbäck
Mar 19, 1983·Lancet
Nov 1, 1983·Acta paediatrica Scandinavica·L A HansonR Zetterström

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