Effect of decentralization and partial outflow obstruction on cholinergic receptors in urinary bladder of rabbit

Urology
J B SmithG F Anderson

Abstract

In this study we have examined the cholinergic receptor density on the detrusor smooth muscle from rabbits with decentralized autonomous bladders and animals with partial outlet obstructions using (3H) quinuclidinyl benzilate ([3H] QNB). Decentralized spinal bladders were obtained from rabbits made paraplegic by a twenty-minute ischemic lesion to the lumbar and sacral spinal cord. Bladder tissues from these rabbits were studied from one, two, five, and nine-day intervals after the ischemic lesion. The affinity of the muscarinic binding sites for (3H) QNB was virtually unchanged at any of the time intervals, while the total Bmax was significantly reduced at one and two days but recovered to normal levels by the fifth and ninth day after the ischemic lesion, provided the bladder had been effectively manually emptied on a regular basis. In a parallel study animals with a partial outlet obstruction or spinal animals with marked bladder distention at the time of sacrifice showed that the cholinergic receptor density was significantly reduced.

References

Nov 1, 1976·Urology·A C Diokno, R Koppenhoefer
Jan 1, 1970·Scandinavian Journal of Urology and Nephrology·B E Glahn
Mar 15, 1981·Analytical Biochemistry·I S JamallS S Que Hee
Mar 1, 1980·Stroke; a Journal of Cerebral Circulation·J A Zivin, U DeGirolami

Related Concepts

Metazoa
Urinary Bladder
Bladder Neck Obstruction
Neurogenic Urinary Bladder, Uninhibited
Quinuclidinyl Benzilate
Chinchilla Rabbits
Radioligand Assay
Cholinergic Receptors
Tritium

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Lipidomics & Rhinovirus Infection

Lipidomics can be used to examine the lipid species involved with pathogenic conditions, such as viral associated inflammation. Discovered the latest research on Lipidomics & Rhinovirus Infection.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Torsion Dystonia

Torsion dystonia is a movement disorder characterized by loss of control of voluntary movements appearing as sustained muscle contractions and/or abnormal postures. Here is the latest research.

Generating Insulin-Secreting Cells

Reprogramming cells or using induced pluripotent stem cells to generate insulin-secreting cells has significant therapeutic implications for diabetics. Here is the latest research on generation of insulin-secreting cells.

Central Pontine Myelinolysis

Central Pontine Myelinolysis is a neurologic disorder caused most frequently by rapid correction of hyponatremia and is characterized by demyelination that affects the central portion of the base of the pons. Here is the latest research on this disease.

Epigenome Editing

Epigenome editing is the directed modification of epigenetic marks on chromatin at specified loci. This tool has many applications in research as well as in the clinic. Find the latest research on epigenome editing here.