Effect of decidua angiogenic factors on experimental dermis allografts.

Burns : Journal of the International Society for Burn Injuries
H BurgosB Hirshowitz

Abstract

Meshed human dermis allografts containing human uterine angiogenic factor were implanted over full thickness surgical skin wounds in rats. Enhanced angiogenesis of the wound bed, three times more than that observed in control grafts, was found in experimental grafts at 3 days postimplantation. This was accompanied by a greater amount of granulation tissue formation, enhanced granulation tissue penetration into the dermal grafts and accelerated incorporation of the grafts. Angiogenesis of the wound bed regressed to control levels at 7 days postimplantation. The growth and penetration of the granulation tissue and the accelerated incorporation of the dermis grafts, however, continued ahead in the experimental grafts while necrosis appeared in the control grafts. The relevance of these results for acceleration of wound healing and improvement of the wound bed for subsequent application of cultured epidermal grafts is discussed. This method may be extended to the treatment of ulcers and burns.

References

Jun 1, 1987·Burns, Including Thermal Injury·A EldadB Gusterson

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Citations

Sep 1, 1993·The Journal of Experimental Zoology·P A Abrahamsohn, T M Zorn
Jul 1, 1992·British Journal of Plastic Surgery·J Nanchahal, C M Ward
Jan 1, 1991·Pharmacology & Therapeutics·R Odedra, J B Weiss
Oct 1, 1995·Tissue Engineering·G G Gallico, N E O'Connor
Dec 10, 1999·American Journal of Reproductive Immunology : AJRI·N LangerE S Lindenbaum
Jan 1, 1992·Scandinavian Journal of Rheumatology·H G FassbenderT Hebert

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