Effect of delayed intervention with ACE-inhibitor therapy on myocyte hypertrophy and growth of the cardiac interstitium in the rat model of myocardial infarction

Journal of Molecular and Cellular Cardiology
K M McDonaldJ N Cohn

Abstract

The effectiveness of angiotensin-converting enzyme (ACE)-inhibitor therapy in attenuating ventricular remodeling when initiated immediately following myocardial damage is clearly established. Less information, however, is available on the impact of late therapy on the remodeling process, especially its influence on the cellular components of these structural changes. The purpose of this study was to examine the effects of converting enzyme inhibitor therapy commenced 28 days following infarction in the rat on changes in cardiac myocyte dimension and the interstitium. At 28 days following infarction, myocyte cell length (153.9+/-7.3 v 131.1+/-5.9 micron, P=0.0002) and cell volume in the free wall of the left ventricle (38. 5+/-5.0 x 10(3) v31.4+/-3.1 x 10(3), P=0.009) had increased compared with sham-operated rats. Similar changes were noted in the septum and right ventricle. Captopril therapy administered between 28 and 56 days attenuated a further increase in cell length noted in an untreated group in the left ventricle (153.5+/-15.3 v 167.3+/-13.7 micron, P=0.02), right ventricle (153.8+/-20.5 v 173.8+/-2.3 micron, P=0.01) and septum (158.0+/-20.2 v 179.1+/-16.6 micron, P=0.004). There was an increase in hydroxyproline conten...Continue Reading

Citations

Mar 21, 2002·Journal of Cardiovascular Pharmacology·Yukie KurosawaHiroshi Narita
Feb 17, 2007·Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre·Andrea P Babick, Naranjan S Dhalla
Mar 6, 1998·The Journal of Laboratory and Clinical Medicine·K M McDonald
Jul 21, 2006·Advances in Enzyme Regulation·Kaoru GotoYasukazu Hozumi
Jun 13, 2013·Journal of Molecular and Cellular Cardiology·Clémence MerlenBruce G Allen
May 17, 2006·Journal of Cardiovascular Pharmacology and Therapeutics·Naranjan S DhallaRamesh K Goyal

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