Effect of delayed maximal androgen blockade therapy for patients with advanced prostate cancer who fail to respond to initial androgen deprivation monotherapy

Japanese Journal of Clinical Oncology
Akio TakayanagiTaiji Tsukamoto

Abstract

We analyzed the efficacy of additional antiandrogens as second- and third-line treatments after the failure of initial androgen deprivation monotherapy. This retrospective study included 53 patients with advanced prostate cancer initially treated with androgen deprivation monotherapy alone. An antiandrogen was added to androgen deprivation monotherapy as the second-line treatment after the failure of the initial androgen deprivation monotherapy. Another antiandrogen, estrogen or steroid was given as the third-line treatment after the second-line treatment failed. The initial androgen deprivation monotherapy was effective in all 53 patients for a median of 9.6 months. Thirty-three (62.3%) patients showed a prostate-specific antigen response to the second-line treatment for a median of 10.7 months. Of the 46 patients who received the third-line treatment, 16 (34.8%) showed a prostate-specific antigen response for a median of 6.0 months. Patients who responded to the second-line treatment had a significantly higher cancer-specific survival rate than those without a response. In multivariate analysis, a nadir prostate-specific antigen of 4.0 ng/ml or greater during androgen deprivation monotherapy and prostate-specific antigen doub...Continue Reading

References

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Oct 8, 2004·The New England Journal of Medicine·Ian F TannockUNKNOWN TAX 327 Investigators
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Jun 19, 2009·Cancer·Hideyuki AkazaUNKNOWN Study Group for the Combined Androgen Blockade Therapy of Prostate Cancer

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Citations

Mar 23, 2012·Japanese Journal of Clinical Oncology·Norihito SogaYoshiki Sugimura
Dec 2, 2011·BJU International·Bob DjavanE David Crawford
Feb 9, 2012·International Urology and Nephrology·Élcio Dias SilvaLeonardo Oliveira Reis

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