PMID: 20099164Jan 26, 2010Paper

Effect of delayed-release 5-fluorouracil implants on colorectal cancer

Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery
Ning WangWei Zheng

Abstract

To study the antitumor effect of peri-tumor implantation of delayed-release 5-fluorouracil implants on xenograft colorectal tumor in mice. Fifty tumor-bearing nude mice were randomly divided into 5 groups. Group A and B were treated with peri-tumor implantation of 5-fluorouracil implants and the dose of 5-fluorouracil was 200 and 100 mg/kg, respectively. Group C and D were treated with peri-tumor injection of 5-fluorouracil solution and the dose of 5-fluorouracil was 200 and 100 mg/kg, respectively. Group E did not receive any treatment. A growth curve was plotted for changes in tumor volume, the weight of the tumor was measured and tumor inhibition rate was calculated. The growth curve was mild in group A and B and steep in group C, D and E. There were statistical differences in tumor volume between groups A and B and other groups and there were no statistical differences in tumor volume among group C, D and E. After 12 days, tumor inhibition rate was 72% in group A, 51% in group B, 8% in group C, and 5% in group C. There were statistical differences in inhibition rate between group A, B and C, D (P<0.05). The weight changes before and after the treatment among the 5 groups were not statistically different. During the study, 1...Continue Reading

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