Effect of delayed sampling on umbilical cord arterial and venous lactate and blood gases in clamped and unclamped vessels.

Archives of Disease in Childhood. Fetal and Neonatal Edition
L Armstrong, B J Stenson

Abstract

Cord blood lactate at birth is a marker of antenatal hypoxia, and is comparable to pH as a prognostic tool. To determine, by a prospective observational study, the effect of delayed sampling from arteries and veins that were double clamped to isolate the blood from the placenta (clamped), and from vessels that were not isolated from the placenta (unclamped). Paired samples taken from clamped and unclamped vessels at 0, 20, 40, and 60 minutes were analysed for lactate, base excess, pH, and Pco(2). Data were analysed as the change from time 0 at 20, 40, and 60 minutes. Thirty eight placentas of infants delivered by elective caesarean section were studied. Arterial samples were taken from 20 placentas, and venous samples from 18 placentas. Arterial and venous lactate was significantly higher than at time 0 by 20 minutes in both clamped and unclamped vessels. Changes in unclamped vessels were greater than in clamped vessels. The pH remained unchanged over 60 minutes in clamped vessels, but changed significantly in unclamped vessels. Base excess changed significantly in both clamped and unclamped vessels. Cord blood samples taken after 20 minutes delay are unreliable for lactate measurement, even if the vessel has been doubly clampe...Continue Reading

References

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Citations

Oct 24, 2007·Archives of Disease in Childhood. Fetal and Neonatal Edition·L Armstrong, B J Stenson
Nov 1, 2006·Archives of Disease in Childhood. Fetal and Neonatal Edition·Adrienne Lynn, Philip Beeby
May 26, 2010·Archives of Gynecology and Obstetrics·Catalina De PacoLuis Navarrete
Aug 9, 2011·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Christopher R H WhiteCraig E Pennell
May 20, 2015·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Peiying LiuHanzhang Lu
Mar 13, 2012·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Javier ValeroAlfredo Perales
May 7, 2015·American Journal of Human Biology : the Official Journal of the Human Biology Council·Isabella EcheverriCecilia Aguilar-de Plata
Sep 4, 2007·Clinics in Perinatology·Isaac Blickstein, Tamar Green
Oct 23, 2016·Journal de gynécologie, obstétrique et biologie de la reproduction·F KellenbergerB Langer
Oct 5, 2016·Journal of Paediatrics and Child Health·Shailender MehtaKei Lui
Apr 5, 2017·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·E R AllansonJ E Dickinson
Aug 7, 2018·Acta Obstetricia Et Gynecologica Scandinavica·Mariarosaria Di Tommaso, Silvia Vannuccini
Jan 9, 2015·Molecular Biology of the Cell·Nilay Y ThakarErnst J Wolvetang
Sep 19, 2017·Acta Obstetricia Et Gynecologica Scandinavica·Serena XodoVincenzo Berghella
Oct 1, 2020·Animals : an Open Access Journal From MDPI·Billie-Jaye BroughamWilliam H E J van Wettere
Mar 18, 2020·Journal of Obstetrics and Gynaecology Canada : JOGC = Journal D'obstétrique Et Gynécologie Du Canada : JOGC·Sharon Dore, William Ehman
Mar 18, 2020·Journal of Obstetrics and Gynaecology Canada : JOGC = Journal D'obstétrique Et Gynécologie Du Canada : JOGC·Sharon Dore, William Ehman

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