Effect of delta9-tetrahydrocannabinol on in vitro sensitization of mouse splenic lymphocytes

Immunological Communications
S S Lefkowitz, K Klager


The effects of delta9-tetrahydrocannabinol (delta9-THC) on the immune response of murine cells sensitized in vitro was determined using a plaque-forming cell (PFC) assay. Splenic lymphocytes from mice injected with delta9-THC showed a depressed immunologic response when compared with cells from control animals which were identically sensitized in vitro with sheep erythrocytes (SRBC). The direct addition of delta9-THC to the culture media altered the immunological response as demonstrated by a reduction in the number of PFC.


Oct 1, 1976·The Journal of Allergy and Clinical Immunology·G S RachelefskyE R Stiehm
Dec 1, 1975·Toxicology and Applied Pharmacology·R W FleischmanH Rosenkrantz
Sep 1, 1975·Journal of Toxicology and Environmental Health·H RosenkrantzH J Esber
Sep 7, 1974·Lancet·J D TealeV Marks
Feb 1, 1974·Science·G G NahasA Morishima
Apr 1, 1971·The Journal of Pharmacy and Pharmacology·B T HoJ E Idänpään-Heikkilä
Nov 22, 1974·Science·M J Silverstein, P J Lessin
Oct 24, 1974·The New England Journal of Medicine·S GuptaP Cushman
Nov 15, 1972·American Journal of Obstetrics and Gynecology·M A Stenchever, M Allen
Oct 1, 1971·Annals of Internal Medicine·B LiskowC W Parker
Sep 1, 1967·The Journal of Experimental Medicine·R I Mishell, R W Dutton


Apr 17, 2015·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Toby K Eisenstein, Joseph J Meissler
Jan 1, 1980·Journal of Immunopharmacology·J A Levy, G H Heppner

Related Concepts

Antibody-Secreting Cells
Hemolytic Plaque Technique
Immunosuppressive Agents
Lymphoid Cells
Tetrahydrocannabinol, Trans-(+-)-Isomer

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Synthetic Genetic Array Analysis

Synthetic genetic arrays allow the systematic examination of genetic interactions. Here is the latest research focusing on synthetic genetic arrays and their analyses.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Computational Methods for Protein Structures

Computational methods employing machine learning algorithms are powerful tools that can be used to predict the effect of mutations on protein structure. This is important in neurodegenerative disorders, where some mutations can cause the formation of toxic protein aggregations. This feed follows the latests insights into the relationships between mutation and protein structure leading to better understanding of disease.

Congenital Hyperinsulinism

Congenital hyperinsulinism is caused by genetic mutations resulting in excess insulin secretion from beta cells of the pancreas. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Epigenetic Memory

Epigenetic memory refers to the heritable genetic changes that are not explained by the DNA sequence. Find the latest research on epigenetic memory here.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Femoral Neoplasms

Femoral Neoplasms are bone tumors that arise in the femur. Discover the latest research on femoral neoplasms here.