Effect of delta9-tetrahydrocannabinol on in vitro sensitization of mouse splenic lymphocytes

Immunological Communications
S S Lefkowitz, K Klager

Abstract

The effects of delta9-tetrahydrocannabinol (delta9-THC) on the immune response of murine cells sensitized in vitro was determined using a plaque-forming cell (PFC) assay. Splenic lymphocytes from mice injected with delta9-THC showed a depressed immunologic response when compared with cells from control animals which were identically sensitized in vitro with sheep erythrocytes (SRBC). The direct addition of delta9-THC to the culture media altered the immunological response as demonstrated by a reduction in the number of PFC.

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Citations

Apr 17, 2015·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Toby K Eisenstein, Joseph J Meissler
Jan 1, 1980·Journal of Immunopharmacology·J A Levy, G H Heppner

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