Effect of demyelinating ulnar nerve injury on strength and fatigue

Journal of Clinical Neuromuscular Disease
Matti D Allen, Timothy J Doherty

Abstract

Conduction block (CB) from focal neuropathy is often associated with weakness and fatigue in affected muscles. Ulnar neuropathy at the elbow (UNE) provides an excellent model to examine the relationships between electrophysiologically defined CB and quantitative measurement of weakness and fatigue. Eight healthy control subjects (47 ± 14 years) and nine patients (53 ± 3 years) with clinical and electrophysiological features of UNE with CB were studied. All underwent bilateral, ulnar motor nerve conduction studies recording from the first dorsal interosseous muscle as well as quantitative measurement of strength and fatigue of the first dorsal interosseous with a custom dynamometer. Strength and fatigue were similar in the dominant and nondominant hands of control subjects and unaffected limb in patients. Varying degrees of conduction block (14-62%, mean 36%) and conduction slowing (31 m/s ± 7) were observed in those with UNE. CB was associated with significant reductions in strength (42%) and fatigue (23%) on a timed fatigue task. The reductions in strength (r = 0.74) and fatigue (r = 0.60) were strongly correlated with the degree of CB. CB in UNE defined by electrophysiological criteria was strongly correlated with weakness an...Continue Reading

References

Jan 1, 1984·Journal of Neurology·R J van der PloegJ Reuvekamp
Feb 7, 1998·American Journal of Physical Medicine & Rehabilitation·K A Kuhlman, W J Hennessey
May 8, 1998·Muscle & Nerve·M K FloeterM Hallett
Jul 25, 2000·Brain : a Journal of Neurology·R KajiH Shibasaki
Feb 14, 2006·Muscle & Nerve·Bradley V WatsonTimothy J Doherty
Feb 1, 2007·Brain : a Journal of Neurology·Cindy Shin-Yi LinMatthew C Kiernan
Nov 3, 2010·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Bradley V Watson, Timothy J Doherty

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