PMID: 6402563Mar 1, 1983Paper

Effect of denervation and reinnervation on oxidation of [6-14C]glucose by rat skeletal muscle homogenates

Journal of Neurochemistry
D C DuBois, S R Max

Abstract

We studied the effects of denervation and reinnervation of the rat extensor digitorum longus muscle (EDL) on the oxidation of [6-14C]glucose to 14CO2. The rate of 14CO2 production decreased dramatically following denervation, and the decrease became significant 20 days after nerve section. Prior to day 20, changes apparently reflected the decline of muscle mass. Decreased 14CO2 production was due to reduced capacity of the enzymatic system (apparent Vmax); there was no change in apparent affinity for glucose (apparent Km). Mixing experiments revealed that the loss of oxidative capacity following denervation is not caused by production of soluble inhibitors by degenerating muscle. Oxidative metabolism, as measured by 14CO2 evolution, recovered during reinnervation. Surprisingly, the specific activity in reinnervated muscles displayed an "overshoot" of approximately 50%, which returned to control by day 60, possibly reflecting increased energy demand by the growing muscle. The time-course of the denervation-mediated change indicates that altered oxidative capacity is secondary to events that initiate denervation changes in muscle. Nevertheless, diminished oxidative capacity may be of considerable metabolic significance in denerva...Continue Reading

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Citations

Jun 6, 2006·Journal of Muscle Research and Cell Motility·Hualin SunXiaosong Gu
Aug 1, 1988·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·D W ZochodneC F Bolton
Jan 5, 2002·Physiological Genomics·B B NgimbousJ M Moalic
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