Effect of denervation of the locus coeruleus projections by DSP-4 treatment on [3H]-raclopride binding to dopamine D(2) receptors and D(2) receptor-G protein interaction in the rat striatum

Brain Research
Jaanus HarroAgo Rinken

Abstract

Changes in the control of dopaminergic neurotransmission by noradrenergic locus coeruleus (LC) projections has been implicated in such disorders as depression, drug addiction, and Parkinson's disease. In the present study, the effect of DSP-4, a neurotoxin highly selective for LC projections, on D(2) receptor abundance as assessed by [3H]-raclopride binding in the striatum was studied in rats after administration in doses of 10 and 50 mg/kg either 3 days or 1 month before decapitation. Three days after DSP-4 the levels of noradrenaline in the frontal cortex were dose-dependently reduced; after 1 month, noradrenaline levels were lowered only by the higher dose. DOPAC levels were dose-dependently reduced in the frontal cortex and striatum 3 days but not 1 month after DSP-4 treatment. Cortical 5-HIAA levels were reduced 3 days but not 1 month after DSP-4. The apparent number of D(2) receptor binding sites in the striatum was higher 1 month after either dose of DSP-4. DSP-4 treatment had no effect on [3H]-raclopride binding affinity, the ability of dopamine (DA) to compete with [3H]-raclopride binding and to activate [35S]GTPgammaS binding or on the binding affinities of GDP and [35S]GTPgammaS for corresponding G proteins 1 month a...Continue Reading

References

Sep 19, 1983·Neuroscience Letters·H R OlpeM W Steinmann
Jan 1, 1993·Journal of Neural Transmission. General Section·J GrenhoffT H Svensson
Oct 9, 2002·Proceedings of the National Academy of Sciences of the United States of America·David WeinshenkerRichard D Palmiter
Dec 14, 2002·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Riina HäidkindJaanus Harro

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Citations

May 16, 2012·Attention Deficit and Hyperactivity Disorders·Joachim HauserKlaus W Lange
Aug 1, 2012·European Journal of Medicinal Chemistry·Reet Reinart-OkugbeniTõnis Kanger
Sep 27, 2008·Journal of Pharmacological Sciences·Argo VonkAgo Rinken
May 21, 2009·Bioorganic & Medicinal Chemistry·Laura HermAttila Sipos
Sep 18, 2007·The European Journal of Neuroscience·Victoria WindleDale Corbett

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