PMID: 6255378Dec 1, 1980

Effect of denervation on the endogenous phosphorylating activity in the cytosol of rat skeletal muscle

Neuroscience Letters
S P SquintoI R Held


An endogenous phosphorylating activity is demonstrated in the cytosol from soleus muscle of the rat which is markedly stimulated after severing the motor nerve fibers to this muscle. The [gamma-32P]AT[ phosphotransferase reaction is heat-labile, dependent upon Mg2+ but not Ca2+ or cyclic GMP, inhibited by a cyclic AMP dependent protein kinase inhibitor, and directly related to the amount of cytosolic protein which provides the endogenous source of both the protein kinase enzyme, ATP, cyclic AMP and phosphorylatable protein substrate. The time-course of the delayed transitory stimulation of the cytosolic phosphorylating activity of the denervated soleus may involve neurotropic factors.

Related Concepts

Cyclic AMP, (R)-Isomer
Cytoplasmic Matrix
Egtazic Acid Potassium Salt
Muscle Denervation Procedure
Muscle Proteins

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