PMID: 3754781Apr 16, 1986Paper

Effect of depletion of spinal cord norepinephrine on morphine-induced antinociception

Brain Research
I H Pang, M R Vasko

Abstract

We studied whether antinociception produced by injection of morphine into the nucleus reticularis paragigantocellularis (NRPG) or by superfusion onto the spinal cord involved norepinephrine (NE)-containing neurons that descend from brainstem into the spinal cord. Spinal cord NE concentrations were depleted with the neurotoxin, 6-hydroxydopamine, and antinociception was measured following morphine injection into NRPG or onto spinal cord. Depletion of cord NE by approximately 90% did not attenuate the antinociceptive effect of either 2 or 10 micrograms of morphine injected intrathecally. In contrast, the depletion did significantly attenuate the antinociceptive effect of 2.5 micrograms morphine injected bilaterally into the NRPG. These results suggest that NE-containing neurons descending from brainstem nuclei into the spinal cord are not important in the analgesia produced by injecting morphine directly onto the spinal cord but may be involved with analgesia produced by morphine injection into the NRPG.

References

Feb 1, 1979·Anesthesiology·J K WangJ E Thomas
Jan 1, 1976·Biochemical Pharmacology·S GarattiniM C Roncaglioni
Jun 25, 1976·Science·T L Yaksh, T A Rudy
Nov 1, 1972·European Journal of Pharmacology·B D Görlitz, H H Frey
May 12, 1980·Brain Research·S V Reddy, T L Yaksh
Sep 1, 1983·Annals of Neurology·O LindvallG Skagerberg
Mar 14, 1983·Brain Research·K N WestlundJ D Coulter

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Citations

Feb 1, 1987·Pharmacology, Biochemistry, and Behavior·C W LoomisF Cervenko
Jan 1, 1987·Pharmacology, Biochemistry, and Behavior·C W LoomisF W Cervenko
Jul 23, 2003·Pharmacology, Biochemistry, and Behavior·Seong-Soo ChoiHong-Won Suh
Jul 16, 2010·Clinical and Experimental Pharmacology & Physiology·Bo XuYu-Qiu Zhang
Apr 22, 1988·The Journal of Comparative Neurology·K L Casey, T J Morrow

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