Effect of depot medroxyprogesterone acetate on postpartum depression

Contraception
Rita Tsai, Jonathan Schaffir

Abstract

Depot medroxyprogesterone acetate (DMPA) is commonly prescribed to women immediately postpartum due to its efficacy, convenience and lack of estrogen. It is unclear whether administering a progestin injection can affect the course of postpartum depression (PPD), which some suspect to be influenced by hormonal changes. In this retrospective study, the objective was to determine whether DMPA administered immediately postpartum influences the development of PPD. A retrospective review of a total of 404 charts was conducted of clinic patients who were scheduled for 6-week postpartum visits at a major medical center, where all patients are routinely asked to complete the Edinburgh Postnatal Depression Scale (EPDS). The average scores on the EPDS at these visits were compared between patients who had received DMPA prior to postpartum discharge from the hospital and patients who had not received any hormonal contraception by using an unpaired t test. In addition, the proportions of women diagnosed with PPD via the scale were compared via contingency tables. Fifty-five women who had received immediate DMPA were compared with 192 women with no hormonal contraception after delivery. The groups were similar in parity, race, mode of delive...Continue Reading

References

Jan 1, 1991·The British Journal of Psychiatry : the Journal of Mental Science·A SteinP J Cooper
Aug 1, 1990·The British Journal of Psychiatry : the Journal of Mental Science·L Murray, A D Carothers
Jun 1, 1987·The British Journal of Psychiatry : the Journal of Mental Science·J L CoxR Sagovsky
Mar 8, 1995·JAMA : the Journal of the American Medical Association·D C SkeggD B Thomas
May 24, 2000·The Journal of Adolescent Health : Official Publication of the Society for Adolescent Medicine·C Stevens-SimonJ Wallis
Apr 25, 2001·Journal of Psychosomatic Obstetrics and Gynaecology·A C Granger, M R Underwood
Jul 26, 2003·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·J Karuppaswamy, R Vlies
May 11, 2005·Archives of Women's Mental Health·V LindahlL Colpe
Oct 15, 2009·Journal of Clinical Psychology·Michael W O'Hara

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Citations

Sep 30, 2014·Clinical Obstetrics and Gynecology·Stephanie Sober, Courtney A Schreiber
Apr 24, 2016·Journal of Obstetrics and Gynaecology Canada : JOGC = Journal D'obstétrique Et Gynécologie Du Canada : JOGC·Amanda BlackAnne Marie Whelan
Apr 24, 2016·Journal of Obstetrics and Gynaecology Canada : JOGC = Journal D'obstétrique Et Gynécologie Du Canada : JOGC·Amanda BlackAnne Marie Whelan
Jan 28, 2014·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Ali SevenMurat Ozekinci
Apr 30, 2014·Expert Opinion on Pharmacotherapy·Deborah R KimKatherine L Wisner
Mar 10, 2015·Journal of Women's Health·Jessica L CastilhoVlada V Melekhin
Apr 1, 2016·The Journal of Family Planning and Reproductive Health Care·Mandisa Singata-MadlikiTheresa A Lawrie
Jul 22, 2017·The European Journal of Contraception & Reproductive Health Care : the Official Journal of the European Society of Contraception·G S Merki-FeldJ Bitzer
Mar 29, 2019·The European Journal of Contraception & Reproductive Health Care : the Official Journal of the European Society of Contraception·Angeline Ti, Kathryn M Curtis
Jul 20, 2019·Therapeutic Advances in Psychopharmacology·Alexandre González-Rodríguez, Mary V Seeman
Feb 23, 2019·CNS Drugs·Ariela FriederKristina M Deligiannidis
Aug 23, 2016·Journal of Women's Health·Audrey BinetteRobert L Reid
Nov 10, 2020·The European Journal of Contraception & Reproductive Health Care : the Official Journal of the European Society of Contraception·Carolyn M RossJessica W Kiley
Oct 29, 2020·Menopause : the Journal of the North American Menopause Society·Shelley N DolitskyJames H Segars
Jul 30, 2020·Best Practice & Research. Clinical Obstetrics & Gynaecology·Lindsay R StandevenLauren M Osborne
Apr 27, 2021·The Linacre Quarterly·William V WilliamsKathleen M Raviele

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