PMID: 36634Feb 1, 1979

Effect of desglycinamide(9)-lysine(8)-vasopressin and prolyl-leucyl-glycinamide on oral ethanol intake in the rat

Pharmacology, Biochemistry, and Behavior
R F Mucha, H Kalant


Rats given ethanol in their drinking water at a concentration that permitted adequate fluid intake gradually accepted higher concentrations and consumed larger amounts of ethanol. These increases were augmented when daily subcutaneous injections of 1 microgram of desglycinamide9-lysine8-vasopressin (DGLVP) or 10 microgram of prolyl-leucyl-glycinamide (PLG) were given concomitantly. Nonsignificant changes in ethanol consumption were seen with injections of 1 microgram PLG, or 0.42 or 42 microgram of lysine8-vasopressin (LVP). In a second experiment 4 microgram DGLVP given every second day as a long-acting zinc phosphate complex, commencing after the increases in ethanol intake had taken place, failed to produce any change in ethanol consumption subsequently. In both Experiments 1 and 2, the rats were switched from forced ethanol intake to a choice between ethanol and tap water. On these tests there was only marginal evidence of peptide-produced changes in ethanol intake.


May 30, 1980·European Journal of Pharmacology·H RigterJ Crabbe
Aug 1, 1990·Pharmacology, Biochemistry, and Behavior·A D RossL A Grupp
Jan 1, 1983·Neuroscience and Biobehavioral Reviews·T K von AlmenR D Olson
Jan 1, 1985·Neuroscience and Biobehavioral Reviews·P J Kulkosky
Jan 1, 1983·Pharmacology & Therapeutics·R F RitzmannW Krivoy
Jan 1, 1982·Annals of the New York Academy of Sciences·Q J PittmanF E Bloom
Jan 1, 1982·Annals of the New York Academy of Sciences·H Rigter, J Crabbe


Apr 15, 1976·Psychopharmacologia·H Rigter, A Popping
Oct 1, 1978·Pharmacology, Biochemistry, and Behavior·F FinkelbergA E Blanc
May 15, 1977·European Journal of Pharmacology·J M Van Ree, D de Wied
Nov 1, 1976·Life Sciences·J M Van Ree, D de Wied
Oct 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·R WalterL B Flexner
Jan 1, 1973·Pharmacology, Biochemistry, and Behavior·N K Mello
May 1, 1966·Proceedings of the Society for Experimental Biology and Medicine·D de Wied

Related Concepts

Ethanol Measurement
Subcutaneous Injections
Antidiuretic Hormone Measurement
Zinc phosphate
Urine Lysine Measurement
Vasopressin (USP)
MSH Release-Inhibiting Hormone
Alcohol Consumption

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