PMID: 36634Feb 1, 1979

Effect of desglycinamide(9)-lysine(8)-vasopressin and prolyl-leucyl-glycinamide on oral ethanol intake in the rat

Pharmacology, Biochemistry, and Behavior
R F Mucha, H Kalant

Abstract

Rats given ethanol in their drinking water at a concentration that permitted adequate fluid intake gradually accepted higher concentrations and consumed larger amounts of ethanol. These increases were augmented when daily subcutaneous injections of 1 microgram of desglycinamide9-lysine8-vasopressin (DGLVP) or 10 microgram of prolyl-leucyl-glycinamide (PLG) were given concomitantly. Nonsignificant changes in ethanol consumption were seen with injections of 1 microgram PLG, or 0.42 or 42 microgram of lysine8-vasopressin (LVP). In a second experiment 4 microgram DGLVP given every second day as a long-acting zinc phosphate complex, commencing after the increases in ethanol intake had taken place, failed to produce any change in ethanol consumption subsequently. In both Experiments 1 and 2, the rats were switched from forced ethanol intake to a choice between ethanol and tap water. On these tests there was only marginal evidence of peptide-produced changes in ethanol intake.

References

May 30, 1980·European Journal of Pharmacology·H RigterJ Crabbe
Aug 1, 1990·Pharmacology, Biochemistry, and Behavior·A D RossL A Grupp
Jan 1, 1983·Neuroscience and Biobehavioral Reviews·T K von AlmenR D Olson
Jan 1, 1985·Neuroscience and Biobehavioral Reviews·P J Kulkosky
Jan 1, 1983·Pharmacology & Therapeutics·R F RitzmannW Krivoy
Jan 1, 1982·Annals of the New York Academy of Sciences·Q J PittmanF E Bloom
Jan 1, 1982·Annals of the New York Academy of Sciences·H Rigter, J Crabbe

Citations

Apr 15, 1976·Psychopharmacologia·H Rigter, A Popping
Oct 1, 1978·Pharmacology, Biochemistry, and Behavior·F FinkelbergA E Blanc
May 15, 1977·European Journal of Pharmacology·J M Van Ree, D de Wied
Nov 1, 1976·Life Sciences·J M Van Ree, D de Wied
Oct 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·R WalterL B Flexner
Jan 1, 1973·Pharmacology, Biochemistry, and Behavior·N K Mello
May 1, 1966·Proceedings of the Society for Experimental Biology and Medicine·D de Wied

Related Concepts

Ethanol
Ethanol Measurement
Subcutaneous Injections
Antidiuretic Hormone Measurement
Zinc phosphate
Lysine
Urine Lysine Measurement
Vasopressin (USP)
MSH Release-Inhibiting Hormone
Alcohol Consumption

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Sexual Dimorphism in Neurodegeneration

There exist sex differences in neurodevelopmental and neurodegenerative disorders. For instance, multiple sclerosis is more common in women, whereas Parkinson’s disease is more common in men. Here is the latest research on sexual dimorphism in neurodegeneration

HLA Genetic Variation

HLA genetic variation has been found to confer risk for a wide variety of diseases. Identifying these associations and understanding their molecular mechanisms is ongoing and holds promise for the development of therapeutics. Find the latest research on HLA genetic variation here.

Super-resolution Microscopy

Super-resolution microscopy is the term commonly given to fluorescence microscopy techniques with resolutions that are not limited by the diffraction of light. Here are the latest discoveries pertaining to super-resolution microscopy.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells.

Brain Lower Grade Glioma

Low grade gliomas in the brain form from oligodendrocytes and astrocytes and are the slowest-growing glioma in adults. Discover the latest research on these brain tumors here.

CD4/CD8 Signaling

Cluster of differentiation 4 and 8 (CD8 and CD8) are glycoproteins founds on the surface of immune cells. Here is the latest research on their role in cell signaling pathways.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.