Effect of design on the performance of a dry powder inhaler using computational fluid dynamics. Part 2: Air inlet size

Journal of Pharmaceutical Sciences
Matthew S CoatesJudy A Raper

Abstract

This study investigates the effect of air inlet size on (i) the flowfield generated in a dry powder inhaler, and (ii) the device-specific resistance, and the subsequent effect on powder deagglomeration. Computational fluid dynamics (CFD) analysis was used to simulate the flowfield generated in an Aerolizer with different air inlet sizes at 30, 45, and 60 l/min. Dispersion performance of the modified inhalers was measured using mannitol powder and a multistage liquid impinger at the same flow rates. The air inlet size had a varying effect on powder dispersion depending on the flow rate. At low flow rates (30 and 45 l/min), reducing the air inlet size increased the inhaler dispersion performance by increasing the flow turbulence and particle impaction velocities above their critical levels for maximal powder dispersion. At 60 l/min, reducing the air inlet size reduced the inhaler dispersion performance by releasing a large amount of powder from the device before the turbulence levels and particle impaction velocities could be fully developed. The results demonstrate that the maximal inhaler dispersion performance can be predicted if details of the device flowfield are known.

References

Feb 2, 1994·Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine·A R Clark, A M Hollingworth
Jul 10, 2002·AAPS PharmSci·Denis GossenDiamon Gangji
Nov 14, 2002·International Journal of Pharmaceutics·Austin Voss, Warren H Finlay

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Citations

Mar 27, 2013·International Journal of Pharmaceutics·J MilenkovicC Kiparissides
May 27, 2009·Journal of Aerosol Medicine and Pulmonary Drug Delivery·P Worth Longest, Michael Hindle
Jan 28, 2012·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Liqun JiangJiabi Zhu
Mar 20, 2009·The AAPS Journal·Pedro J MendesJoão F Pinto
Apr 6, 2012·The AAPS Journal·Wallace P AdamsAnthony J Hickey
Mar 3, 2012·Chemical & Pharmaceutical Bulletin·Daiki HiraHirokazu Okamoto
Dec 4, 2013·International Journal of Pharmaceutics·J MilenkovicC Kiparissides
May 14, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Michael Yifei YangHak-Kim Chan
Nov 13, 2014·Expert Opinion on Drug Delivery·Priya MuralidharanHeidi M Mansour
Apr 16, 2014·Advanced Drug Delivery Reviews·Qi Tony ZhouHak-Kim Chan
Jan 8, 2013·Expert Opinion on Drug Delivery·Conor A RuzyckiWarren H Finlay
Dec 7, 2013·Journal of Pharmaceutical Sciences·Srinivas R B BeharaMichael Hindle
Apr 17, 2014·Advanced Drug Delivery Reviews·M HoppentochtA H de Boer
Nov 9, 2007·Journal of Pharmaceutical Sciences·Handoko AdiDaniela Traini
Nov 19, 2011·Journal of Pharmaceutical Sciences·Martin J DonovanHugh D Smyth
Jan 19, 2016·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Keith T Ung, Hak-Kim Chan
Sep 30, 2014·Pharmaceutical Development and Technology·Tan SuwandechaTeerapol Srichana
Nov 13, 2012·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·S StegemannA Hincal
May 16, 2012·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Srinivas Ravindra Babu BeharaDavid A V Morton
Nov 9, 2011·Advanced Drug Delivery Reviews·William WongPaul M Young
Jun 7, 2011·Advanced Drug Delivery Reviews·P Worth Longest, Landon T Holbrook
May 4, 2010·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Qi Tony ZhouDavid A V Morton
Oct 14, 2008·International Journal of Pharmaceutics·P TangJ A Raper
Aug 14, 2012·The Journal of Pharmacy and Pharmacology·Christian FriebelBernd W Müller
Apr 15, 2014·AAPS PharmSciTech·John Gar Yan ChanHak-Kim Chan
May 20, 2015·International Journal of Pharmaceutics·Mireille HassounBen Forbes
Dec 17, 2014·Pharmaceutical Research·Zhenbo TongRunyu Yang
Sep 24, 2013·International Journal of Pharmaceutics·Nguyen Thi Quynh NgocRaymond Lau
Oct 4, 2011·International Journal of Pharmaceutics·Srinivas Ravindra Babu BeharaPeter Stewart
Sep 24, 2013·International Journal of Pharmaceutics·Lan ChenUmezuruike Linus Opara
Aug 9, 2016·International Journal of Pharmaceutics·Xiang KouM Teresa Carvajal
Sep 30, 2016·The AAPS Journal·Thaigarajan ParumasivamHak-Kim Chan
May 26, 2017·Multidisciplinary Respiratory Medicine·Federico LavoriniOmar S Usmani
Jan 25, 2021·International Journal of Pharmaceutics·Mengyu LiHak-Kim Chan
Feb 13, 2021·Pharmaceutical Research·David F FletcherJulio Soria

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