Effect of desipramine on cerebrospinal fluid concentrations of corticotropin-releasing factor in human subjects

Psychiatry Research
R C VeithC Nemeroff

Abstract

To assess the effect of desipramine (DMI) on corticotropin-releasing-factor (CRF) activity in the central nervous system, we measured cerebrospinal fluid (CSF) concentrations of CRF in healthy volunteers following short-term administration of DMI or placebo. DMI administration for 2 days was associated with a significant dose-related reduction in CRF concentrations. There was a nonsignificant 6% reduction in CRF concentrations among the 10 subjects who received 50 mg DMI (delta CRF: -3 +/- 2 pg/ml) and a significant 14% fall in the CRF concentrations of the eight subjects who received 100 mg DMI (delta CRF: -8 +/- 3 pg/ml). The mean CSF concentration of CRF was unchanged in the six subjects randomized to placebo (delta CRF: 1 +/- 5 pg/ml). DMI administration had no effect on CSF norepinephrine concentrations (n = 24) or on plasma cortisol (n = 25). We conclude that short-term administration of DMI in healthy volunteers is associated with a dose-related reduction in CSF concentrations of CRF.

References

Aug 1, 1988·The Journal of Comparative Neurology·E T Cunningham, P E Sawchenko
Jun 1, 1988·Archives of General Psychiatry·C B NemeroffM Stanley
Sep 1, 1988·The Journal of Clinical Investigation·A E CalogeroP W Gold
Sep 24, 1985·European Journal of Pharmacology·J T HaskinsE B Sigg
Aug 18, 1988·The New England Journal of Medicine·P W GoldG P Chrousos
Feb 1, 1988·The Journal of Clinical Endocrinology and Metabolism·M A RaskindJ B Halter
Jan 1, 1971·Acta Physiologica Scandinavica. Supplementum·U Ungerstedt

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Citations

Jan 22, 1996·Journal of Affective Disorders·A J Mitchell, T R Dening
Nov 5, 2005·Brain Research. Brain Research Reviews·Adrie W Bruijnzeel, Mark S Gold
Sep 26, 2013·Journal of Chemical Neuroanatomy·Jean-Michel Aubry
Feb 24, 2006·NeuroRx : the Journal of the American Society for Experimental NeuroTherapeutics·Paul E Holtzheimer, Charles B Nemeroff
Jan 23, 2003·The Annals of Thoracic Surgery·Virginie Pignay-DemariaLouis P Perrault
Oct 17, 1998·Journal of Psychosomatic Research·D J Newport, C B Nemeroff
Jul 15, 1998·Neuroscience and Biobehavioral Reviews·A J Mitchell
Dec 17, 2009·Molecular Psychiatry·E B Binder, C B Nemeroff
Sep 1, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Adrie W BruijnzeelMark S Gold
Nov 20, 2002·Proceedings of the National Academy of Sciences of the United States of America·Elissa M StromeDoris J Doudet
Mar 22, 1996·Annals of the New York Academy of Sciences·K M HartlineC B Nemeroff
Aug 15, 2015·Neuroscience and Biobehavioral Reviews·R Parrish WatersCliff H Summers
Dec 19, 2006·American Journal of Preventive Medicine·Uma Rao
Feb 7, 2007·Journal of Neuroendocrinology·C Schüle
Nov 20, 2004·The Psychiatric Clinics of North America·Adrie W BruijnzeelMark S Gold
Nov 18, 2006·Expert Opinion on Pharmacotherapy·Paul E Holtzheimer, Charles B Nemeroff
Mar 20, 2010·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Shang-Feng Gao, Ai-Min Bao
Dec 1, 2000·Depression and Anxiety·P H Roseboom, N H Kalin
Oct 2, 2003·Journal of Clinical Psychopharmacology·Koichi NisijimaHisashi Sugiyama
Jun 6, 2009·Harvard Review of Psychiatry·Daniel J Zimmerman, Lois Wonsun Choi-Kain
Jul 11, 2009·Expert Review of Neurotherapeutics·Cornelius SchüleRainer Rupprecht
Feb 28, 2003·The Journal of Pharmacology and Experimental Therapeutics·Michelle L GilmorMichael J Owens
Feb 1, 2000·Journal of Clinical Psychopharmacology·K Nisijima
Apr 22, 2017·Naunyn-Schmiedeberg's Archives of Pharmacology·Andrzej WróbelJarosław Dudka
Jul 22, 1998·The Psychiatric Clinics of North America·P M PlotskyC B Nemeroff

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