Effect of dexamethasone on invasion of human squamous cell carcinoma cells into collagen gel

Cancer Letters
Y HayashidoT Matsuya

Abstract

The effect of dexamethasone (Dex) on the ability to invade type I collagen gel was investigated in two cell lines of oral squamous cell carcinoma (SCC). At concentrations higher than 10(-8) M, Dex significantly suppressed the invasive growth of SCC cells into the gel. The same concentrations of Dex led to a decrease in urokinase type plasminogen activator (u-PA) synthesis and an increase in plasminogen activator inhibitor type 1 (PAI-1) synthesis by SCC cells. These findings suggest that Dex inhibits the invasiveness of SCC cells by decreasing their proteolytic activity.

References

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Citations

Jun 24, 2018·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Luana Samara Balduíno de SenaCassiano Francisco Weege Nonaka
Nov 20, 2004·International Journal of Cancer. Journal International Du Cancer·Brian S WintersRamsey A Foty

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