Effect of dexamethasone on voltage-gated Ca2+ channels and cytosolic Ca2+ in rat chromaffin cells

Neuroreport
L FullerB Jackson

Abstract

The present study examined whether the synthetic glucocorticoid dexamethasone (DEX) can modulate voltage-gated Ca2+ channel (VGCC) activity, and as a consequence agonist-induced increases in cytosolic Ca2+, in cultured rat adrenal medullary chromaffin (RAMC) cells. Exposure to 1 microM DEX for 48 h significantly increased peak VGCC current (delta +140%). DEX treatment also significantly potentiated the increases in cytosolic Ca2+ in response to submaximal stimulatory concentrations of KCl (delta +64%) and nicotine (delta +32%). The Ca2+ channel agonist BAY K-8644 increased both VGCC current (delta +109%) and potentiated the KCl-stimulated increase in cytosolic Ca2+ (delta +35%) to a comparable extent to that seen with DEX. These data suggest that DEX treatment increases VGCC activity, and that this increased Ca2+ influx leads to potentiation of agonist-induced increases in cytosolic Ca2+ in RAMC cells.

Citations

May 29, 2002·Proceedings of the National Academy of Sciences of the United States of America·Guey-Jen Lai, David P McCobb
Dec 12, 2001·Regulatory Peptides·Mark S JorgensenBrian A Jackson
Sep 7, 2011·Neuroscience and Biobehavioral Reviews·Tayfun I Uzbay
Dec 18, 2001·Journal of Neuroscience Research·J LiuB A Jackson
Aug 27, 1999·Journal of Neuroscience Research·P G WagnerB A Jackson
Jun 3, 2005·American Journal of Physiology. Cell Physiology·Jianhua XuFrederick W Tse
Aug 9, 2003·Journal of Neurophysiology·Peter V LovellDavid P McCobb
Dec 23, 2004·Journal of Neuroscience Research·Julye M AdamsBrian A Jackson

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