Effect of dexmedetomidine and cold stress in a rat model of neuropathic pain: Role of interleukin-6 and tumor necrosis factor-α

European Journal of Pharmacology
Hanan Sayed M FarghalyKhaled A Abdel-Sater

Abstract

Dexmedetomidine (Dex) is a novel Alpha 2-adrenoceptor agonist. It decreases sympathetic tone and attenuates the stress responses to anesthesia and surgery. People exposed to cold suffer unpleasant thermal pain, which is experienced as stress and causes the release of noradrenaline from the sympathetic terminals. The present study investigated the effects of cold stress and dexmedetomidine on chronic constriction injury (CCI) model of the sciatic nerve in rats. Sixty four male Wistar rats were divided into seven groups of eight rats each: repeated cold stress (RCS) group, sham RCS group, CCI group, sham CCI group, Dex-treated group received a single dose of Dex (5 μg/kg), CCI+Dex group, CCI+RCS group. Interleukin-6 (IL-6) and tumor necrosis factor- alpha (TNF-α) levels in the serum were measured by enzyme-linked immunosorbent assay. The mean body weight of CCI, RCS, CCI+RCS, CCI+Dex and RCS+Dex groups decreased significantly compared with pre-values. Dexmedetomidine and CCI caused significant changes of the systolic, diastolic and mean blood pressure. Both RCS and CCI groups showed significant decreased of reaction time in the hot plate test. The RCS and CCI groups demonstrated a significant mechanical hyperalgesia, while pain t...Continue Reading

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Citations

May 31, 2018·Cells, Tissues, Organs·Rasha B Abd-EllatiefHassan I Kotb
Aug 28, 2018·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Changming WangZongxiang Tang
Aug 28, 2020·International Journal of Molecular Sciences·Filip JovanovicNebojsa Nick Knezevic
Sep 20, 2018·Scientific Reports·Yonglan RuanZongxiang Tang
May 21, 2020·Frontiers in Neuroscience·Yang ZhaoShilei Wang
Oct 4, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Qi-Hang CaiYuan-Lin Zheng
Aug 27, 2021·Experimental and Therapeutic Medicine·Wenyan ShanJitong Liu

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