Effect of dexmedetomidine on brain edema and neurological outcomes in surgical brain injury in rats.

Anesthesia and Analgesia
Michael BenggonJohn H Zhang

Abstract

Surgical brain injury (SBI) is damage to functional brain tissue resulting from neurosurgical manipulations such as sharp dissection, electrocautery, retraction, and direct applied pressure. Brain edema is the major contributor to morbidity with inflammation, necrosis, oxidative stress, and apoptosis likely playing smaller roles. Effective therapies for SBI may improve neurological outcomes and postoperative morbidities associated with brain surgery. Previous studies show an adrenergic correlation to blood-brain barrier control. The α-2 receptor agonist dexmedetomidine (DEX) has been shown to improve neurological outcomes in stroke models. We hypothesized that DEX may reduce brain edema and improve neurological outcomes in a rat model of SBI. Male Sprague-Dawley rats (n = 63) weighing 280 to 350 g were randomly assigned to 1 of 4 IP treatment groups: sham IP, vehicle IP, DEX 10 mg/kg, and DEX 30 mg/kg. Treatments were given 30 min before SBI. These treatment groups were repeated to observe the physiologic impact of DEX on mean arterial blood pressure (MAP), heart rate (HR), and blood glucose on SBI naïve animals. Rats were also assigned to 4 postinjury IV treatment groups: sham IV, vehicle IV, DEX 10/5, and DEX 30/15 (DEX group...Continue Reading

References

Sep 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·M E RaichleL G Sharpe
Feb 13, 1989·Neuroscience Letters·R N KalariaS I Harik
Jun 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·S I Harik
Dec 10, 1999·Journal of Autonomic Pharmacology·N BorgesI Azevedo
Apr 27, 2001·Anesthesia and Analgesia·A Y BekkerW Doyle
Jun 23, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Marios C PapadopoulosA S Verkman
Sep 3, 2004·Critical Care Medicine·Raymond F MossD Ceri Davies
Dec 24, 2004·Anesthesia and Analgesia·Claudia StapelfeldtPekka O Talke
Feb 3, 2005·Burns : Journal of the International Society for Burn Injuries·Jean CassutoJohanna Räntfors
Jul 14, 2006·Journal of Neuroscience Methods·Gerald MatchettJohn Zhang
Mar 21, 2007·Neuroscience·T Puthussery, E L Fletcher

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Citations

Sep 4, 2015·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Dongki Yang, Jeong Hee Hong
Sep 15, 2020·Chinese Neurosurgical Journal·Zachary D TravisJohn H Zhang

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