Effect of dexmedetomidine on haemodynamic responses to laryngoscopy and intubation : perioperative haemodynamics and anaesthetic requirements

Drugs in R&D
Munise YildizSeref Otelcioglu

Abstract

Dexmedetomidine reduces the dose requirements for opioids and anaesthetic agents. The purpose of this study was to evaluate the effect of a single pre-induction intravenous dose of dexmedetomidine 1 microg/kg on cardiovascular response resulting from laryngoscopy and endotracheal intubation, need for anaesthetic agent and perioperative haemodynamic stability. Fifty patients scheduled for elective minor surgery were randomised into two groups (dexmedetomidine group and placebo group, n = 25 in each group). During and after drug administration, the Ramsey sedation scale was applied every 5 minutes. Fentanyl 1 microg/kg was administered to all patients and thiopental was given until lash reflex disappeared. Anaesthesia continuation was maintained with 50% : 50%, oxygen : nitrous oxide. Sevoflurane concentration was adjusted to maintain systolic blood pressure within 20% of preoperative values. After extubation, the Steward awakening score was applied at 5 and 10 minutes. Haemodynamic parameters and adverse effects were recorded every 10 minutes for 1 hour after surgery. During intubation the need for thiopental and sevoflurane concentration were decreased by 39% and 92%, respectively, in the dexmedetomidine group compared with the...Continue Reading

References

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Citations

Dec 11, 2014·Journal of Neurosurgical Anesthesiology·Kadarapura N GopalakrishnaArimanickam Ganesamoorthi
Apr 9, 2015·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Zhen-Xiu LiuZui Zou
Jan 21, 2017·Clinical Pharmacokinetics·Maud A S WeerinkPieter Colin
Dec 5, 2019·National Journal of Maxillofacial Surgery·Arun KumarGyan Prakash Singh
Jun 13, 2009·European Journal of Anaesthesiology·Freda Richa
Feb 19, 2016·The Cochrane Database of Systematic Reviews·Luise Jessen LundorfAnn Merete Møller
Feb 14, 2013·Experimental and Therapeutic Medicine·Jingjun ChenXueping Han
Jan 16, 2016·JBI Database of Systematic Reviews and Implementation Reports·Jeffrey Hoffman, Casi Hamner
Jul 25, 2019·Frontiers in Pharmacology·Cheng-Yu WangHua-Cheng Liu
May 29, 2015·Clinical and Experimental Pharmacology & Physiology·Na WangRui Wang
Oct 19, 2013·Experimental and Therapeutic Medicine·Jianjun RenZhenming Dong
Jan 17, 2014·Obesity Surgery·Adrian AlvarezAshish C Sinha
Mar 24, 2016·Anesthesia and Analgesia·Bhiken I NaikMarcel E Durieux
May 15, 2010·The Kaohsiung Journal of Medical Sciences·Volkan HanciIşil Ozkoçak Turan
Oct 9, 2015·JBI Database of Systematic Reviews and Implementation Reports·Jeffrey Hoffman, Casi Hamner
Feb 18, 2021·Indian Journal of Ophthalmology·Julie PeguRigalla Laikhuram

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