Effect of dexmedetomidine on pulmonary artery pressure after congenital cardiac surgery: A pilot study

Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
Judith P LazolConstantinos Chrysostomou

Abstract

To characterize the effects of dexmedetomidine on the pulmonary artery pressure in patients after congenital cardiac surgery. Prospective observational pilot study. Pediatric cardiac intensive care unit at a university hospital. Twenty-two patients who received dexmedetomidine after cardiothoracic surgery. None. An echocardiogram was performed at three time points: 1) baseline (T0); 2) 6 mins after dexmedetomidine loading (T1); and 3) 1 hr after initiation of dexmedetomidine infusion (T2). Transthoracic echocardiography was used to estimate pulmonary artery pressure based on tricuspid regurgitant velocity (4 x Velocity2) plus central venous pressure. Twenty-two patients aged 0.9 yrs old (interquartile range, 7.9) were enrolled at a median of 1 hr (1.5) after surgery. Dexmedetomidine loading, 0.62 microg/kg (0.5), was given in all patients followed by 0.5 microg/kg/hr (0.6) at T1 and 0.65 microg/kg/hr (0.5) at T2. None of the patients had any increase in pulmonary artery pressure. Overall, the pulmonary artery pressure decreased from 30 mm Hg (13) at T0 to 24 mm Hg (10) at T1 and 26 mm Hg (8) at T2 (p < .001). The pulmonary artery pressure/systemic systolic blood pressure ratio decreased from 33% (12) at T0 to 23% (15) at T1 and...Continue Reading

References

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Citations

Sep 13, 2011·Pediatric Cardiology·Joseph D TobiasAndrew R Yates
Sep 9, 2010·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Avihu Z Gazit
May 1, 2013·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Felice SuAthena F Zuppa
Jun 4, 2013·Journal of Cardiothoracic and Vascular Anesthesia·Zeynep TosunAdem Boyaci
Aug 20, 2010·Expert Opinion on Drug Safety·Felice Su, Gregory B Hammer
May 23, 2012·Congenital Heart Disease·Constantinos ChrysostomouLee Beerman
Mar 21, 2013·Congenital Heart Disease·Kristin M Burns, E Anne Greene
Nov 2, 2014·Frontiers in Pediatrics·Adam B ChristopherCecilia W Lo
Sep 13, 2016·Journal of Cardiothoracic and Vascular Anesthesia·Reena Khantwal JoshiRaja Joshi
May 28, 2017·Seminars in Cardiothoracic and Vascular Anesthesia·Ricardo RiverosAlparslan Turan
May 6, 2015·Asian Cardiovascular & Thoracic Annals·Tomomi HasegawaShunsuke Matsushima
Aug 9, 2011·Anesthesia and Analgesia·Keira P Mason, Jerrold Lerman
Oct 4, 2011·Anesthesia and Analgesia·Jackson WongKeira P Mason
Mar 6, 2016·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Sarah Scarpace LucasJames A DiNardo
Aug 5, 2016·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Viviane G Nasr, James A DiNardo
Jun 19, 2015·Current Opinion in Anaesthesiology·Joseph D Tobias
Jun 25, 2021·Journal of Pharmacy Practice·Katrin LichtsinnAlexandra Wilson

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