PMID: 7542544Apr 1, 1995Paper

Effect of dextran and enoxaparin on early ePTFE graft thrombogenicity in sheep

European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery
S E MatthiassonB Lindblad

Abstract

To evaluate the effect of low molecular weight heparin (LMWH), dextran 70 and their combination on platelet adhesion and fibrinogen uptake in ePTFE grafts in an experimental sheep model. Prospective open study. Animal Laboratory of a University Hospital. Early thrombogenicity of ePTFE grafts was studied after interposition in the two common carotid arteries of 40 adult sheep. The animals received one of four different treatment regimens in a double blind randomised way: enoxaparin and polygeline, saline and dextran 70, enoxaparin and dextran 70 or saline and polygeline (control). The substances were administered i.v. with a total dose of 73 antifactor-Xa U/kg for enoxaparin and 1.0 g/kg for dextran 70. Polygeline and saline were used as placebo substances in equivalent volumes. On one side (random allocation) the carotid blood flow was restricted to 25 ml/min, on the other side it was left unrestricted. The following variables were studied: 1) fibrinogen uptake; 2) platelet uptake; 3) early graft patency; 4) blood flow in patient grafts; 5) visible presence of graft thrombus; 6) thrombus weight. The results verified the importance of adequate blood flow as only 30% of grafts with restricted blood flow in the control group were ...Continue Reading

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Citations

Mar 20, 2010·Journal of Vascular Surgery·Michael J ByromMartin K C Ng

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