Jan 1, 1977

Effect of dextran and induced thrombocytopenia on the lysability of ex vivo thrombi in dogs

Acta Chirurgica Scandinavica
M AbergU Hedner


The lysability of thrombi and clots was studied in intact and thrombocytopenic dogs. The thrombi were formed in ex vivo in rotating. Chandler loops, the clots were formed in plastic tubes. Infustion of dextran 70 to the intact dogs was followed by a significant increase in the lysability of the thrombi but not of the clots. Thrombocytopenia caused an increase in the lysability of both thrombi and clots. After infusion of dextran to thrombocytopenic dogs a further increase was noted in the lysability of thrombi but not of clots. The results indicate that dextran and induced thrombocytopenia increase the lysability of thrombi by different mechanisms. The different behaviour between thrombi and clots is probably due to the difference in structure between them particularly with regard to the distribution of platelets. It is suggested that dextran decreased the thrombus statility by impairing the platelet surface function.

  • References
  • Citations


  • We're still populating references for this paper, please check back later.
  • References
  • Citations


  • This paper may not have been cited yet.

Mentioned in this Paper

Dextran 70
Complete Blood Count
Blood Clot
Platelet Count Measurement
Fibrin split products

About this Paper

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.

Related Papers

European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
M Aberg, S E Bergentz
© 2020 Meta ULC. All rights reserved