PMID: 12765332May 27, 2003Paper

Effect of dextran-induced changes in refractive index and aggregation on optical properties of whole blood

Physics in Medicine and Biology
Xiangqun XuValery V Tuchin

Abstract

The purpose of the present study is to investigate systematically the mechanisms of alterations in the optical properties of whole blood immersed in the biocompatible agent dextran, and to define the optimal concentration of dextrans required for blood optical clearing in order to enhance the capability of light penetration depth for optical imaging applications. In the experiments, dextrans with different molecular weights and various concentrations were employed and investigated by the use of the optical coherence tomography technique. Changes in light attenuation, refractive index and aggregation properties of blood immersed in dextrans were studied. It was concluded from the results that the mechanisms for blood optical clearing are characteristic of the types of dextrans employed, their concentrations and the application stages. Among the substances applied, Dx500 at a concentration at 0.5 g dl(-1) gives the best result in improving light penetration depth through the blood. The increase of light transmission at the beginning of the addition of dextrans is mainly attributed to refractive index matching between the scattering centres and the ground matter. Thereafter, the transmission change is probably due to a dextran-ind...Continue Reading

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Citations

Feb 19, 2009·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Joseph W VillardMarc D Feldman
Sep 29, 2011·Journal of Biomedical Optics·Xiangqun XuFeifei Fu
Feb 23, 2012·Journal of Biomedical Optics·Deqiu HuangZhouyi Guo
May 10, 2008·Journal of Biomedical Optics·Zongzhen MaoZhenzhen Han
May 10, 2008·Journal of Biomedical Optics·Xiangqun XuZhongping Chen
Jan 12, 2010·Journal of Biomedical Optics·Xiangqun XuZhongping Chen
Oct 23, 2014·Clinical Hemorheology and Microcirculation·Bumseok NamgungSangho Kim
Jul 11, 2009·IEEE Transactions on Visualization and Computer Graphics·Thomas KerwinDon Stredney
Jan 8, 2009·IEEE Transactions on Bio-medical Engineering·Xiangqun XuZhongping Chen
Jul 18, 2012·IEEE Transactions on Bio-medical Engineering·Feifei FuJinhai Geng
Oct 8, 2016·Clinical Hemorheology and Microcirculation·Lian ZhaoHans Bäumler
Aug 25, 2018·Journal of Biomedical Optics·Alexey N BashkatovValery V Tuchin
Sep 3, 2010·Biofabrication·Rui LimaTakami Yamaguchi
Jan 4, 2020·Nature Reviews. Neuroscience·Hiroki R UedaPhilipp J Keller
Mar 13, 2014·Journal of Biomedical Optics·Matti KinnunenValery V Tuchin

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