Effect of dextran on plasma tissue plasminogen activator (t-PA) and plasminogen activator inhibitor-1 (PAI-1) during surgery

Acta Anaesthesiologica Scandinavica
M Eriksson, T Saldeen

Abstract

Dextran is known to increase the plasminogen activation rate in vitro and to decrease the alpha2-antiplasmin activity. We decided to explore the effect of dextran on plasma tissue plasminogen activator (t-PA) and plasminogen activator inhibitor-1 (PAI-1) during surgical trauma. Thirty-one patients undergoing elective surgery were given 500 ml of 6% dextran 70. Another nine patients serving as controls were given 500 ml of a glucose-electrolyte solution. The activities of t-PA and PAI-1 during surgery were determined, as was the concentration of t-PA antigen. PAI-1 activity was decreased by 19% after infusion of 250 ml of dextran. After 500 ml, the activity was reduced by 22% (both P < 0.05). The activity of t-PA was increased by 43% and 29% (both P < 0.05) and the antigenic amount of t-PA was increased by 18% and 15% (both P < 0.05) after infusion of 250 ml and 500 ml of dextran, respectively. No changes in these variables were observed in the control patients. It is concluded that infusion of dextran promotes fibrinolysis by enhancing plasminogen activation in patients subjected to trauma. Since elevated levels of PAI-1 prior to surgery are known to predispose to deep vein thrombosis, which may form already during the operatio...Continue Reading

Citations

Jun 13, 2006·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Philippe Van der Linden, Brigitte E Ickx
Oct 2, 1998·Thrombosis Research·S JavorschiG Freyburger
Aug 19, 1999·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·T M SartoriG Antonio
Feb 22, 2002·Vox Sanguinis·M P W Grocott, M A Hamilton
Feb 15, 2002·Reviews in Clinical and Experimental Hematology·H G WatsonM Greaves
Jun 8, 2001·Critical Care Medicine·E de Jonge, M Levi
Aug 6, 2009·Best Practice & Research. Clinical Anaesthesiology·Sibylle A Kozek-Langenecker
Jun 24, 2008·Journal of Vascular Surgery·Chris I JonesAlison H Goodall
May 11, 2016·Journal of Cardiothoracic and Vascular Anesthesia·Sumeet ReddyPaul Young
Feb 15, 2013·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Vadim KostousovNena Matijevic
Mar 14, 2013·Shock·Fernando Godinho ZampieriLuciano Cesar Pontes Azevedo
Jul 8, 2017·Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine·Peter BentzerThomas Kander

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.