Effect of Dextroamphetamine on Poststroke Motor Recovery: A Randomized Clinical Trial

JAMA Neurology
Larry B GoldsteinJohn Pura

Abstract

Data from animal models show that the administration of dextroamphetamine combined with task-relevant training facilitates recovery after focal brain injury. Results of clinical trials in patients with stroke have been inconsistent. To collect data important for future studies evaluating the effect of dextroamphetamine combined with physiotherapy for improving poststroke motor recovery and to test the efficacy of the approach. This pilot, double-blind, block-randomized clinical trial included patients with cortical or subcortical ischemic stroke and moderate or severe motor deficits from 5 rehabilitation hospitals or units. Participants were screened and enrolled from March 2001 through March 2003. The primary outcome was assessed 3 months after stroke. Study analysis was completed December 31, 2015. A total of 1665 potential participants were screened and 64 were randomized. Participants had to begin treatment 10 to 30 days after ischemic stroke. Data analysis was based on intention to treat. Participants were allocated to a regimen of 10 mg of dextroamphetamine (n = 32) or placebo (n = 32) combined with a 1-hour physical therapy session beginning 1 hour after drug or placebo administration every 4 days for 6 sessions in addit...Continue Reading

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Citations

Oct 9, 2019·Stroke; a Journal of Cerebral Circulation·Hiroki AbeTakuya Takahashi
Dec 21, 2019·Expert Review of Neurotherapeutics·Luis Castilla-GuerraMiguel Angel Colmenero-Camacho
May 13, 2020·Neurocritical Care·David J GagnonDavid B Seder
Jul 22, 2019·Translational Stroke Research·Zohi Sternberg, B Schaller
Nov 12, 2020·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Clemens J Sommer, Wolf-Rüdiger Schäbitz
Jan 13, 2021·Proceedings of the Japan Academy. Series B, Physical and Biological Sciences·Tomoyuki MiyazakiTakuya Takahashi
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Feb 23, 2020·Neuron·Silvestro MiceraAlessandra Pedrocchi
Sep 3, 2021·Neural Regeneration Research·Andreas Rogalewski, Wolf-Rüdiger Schäbitz

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