Effect of dextromethorphan, diphenhydramine, and placebo on nocturnal cough and sleep quality for coughing children and their parents

Pediatrics
Ian M PaulCheston M Berlin

Abstract

To determine whether the commonly used over-the-counter medications dextromethorphan and diphenhydramine are superior to placebo for the treatment of nocturnal cough and sleep difficulty associated with upper respiratory infections and to determine whether parents have improved sleep quality when their children receive the medications when compared with placebo. Parents of 100 children with upper respiratory infections were questioned to assess the frequency, severity, and bothersome nature of the nocturnal cough. Their answers were recorded on 2 consecutive days, initially on the day of presentation, when no medication had been given the previous evening, and then again on the subsequent day, when either medication or placebo was given before bedtime. Sleep quality for both the child and the parent were also assessed for both nights. For the entire cohort, all outcomes were significantly improved on the second night of the study when either medication or placebo was given. However, neither diphenhydramine nor dextromethorphan produced a superior benefit when compared with placebo for any of the outcomes studied. Insomnia was reported more frequently in those who were given dextromethorphan, and drowsiness was reported more com...Continue Reading

References

May 1, 1976·Journal of Clinical Pharmacology·R M RussoJ E Allen
Jun 1, 1977·The Journal of Pediatrics·H E Hestand, D W Teske
Oct 1, 1991·Acta paediatrica Scandinavica·M KorppiM Silvasti
Jul 1, 1990·The American Journal of Emergency Medicine·C M GoetzE P Krenzelok
Jul 1, 1987·The Journal of Allergy and Clinical Immunology·T RothF Zorick
Jan 1, 1989·Clinical Pharmacology and Therapeutics·F GengoJ K Miller
Aug 1, 1988·The American Review of Respiratory Disease·F J CurleyS P Baker
Sep 6, 1986·British Medical Journal·P M Fleming
Jun 1, 1988·Forensic Science International : Synergy·L RammerH Sandler
Jan 1, 1987·Journal of Toxicology. Clinical Toxicology·C KöppelJ Tenczer
Jul 1, 1986·The American Journal of Emergency Medicine·J JonesL Cannon
May 1, 1985·Archives of Disease in Childhood·L N Archer, H Simpson
May 1, 1983·Journal of Clinical Pharmacology·K RickelsR Weinstock
Jun 9, 1994·The New England Journal of Medicine·F E Simons, K J Simons
May 5, 1993·JAMA : the Journal of the American Medical Association·M B Smith, W Feldman
Oct 1, 1993·Southern Medical Journal·S Murray, T Brewerton
Apr 1, 1993·Pediatric Pulmonology·A FalconerP Helms
Apr 3, 1993·BMJ : British Medical Journal·J Walker, L N Yatham
May 1, 1993·The Journal of Pediatrics·J A TaylorJ E Rogers
Jan 1, 1996·Psychosomatics·A Polles, J L Griffith
Oct 1, 1996·The American Journal of Emergency Medicine·S M EmadianR D Herr
Oct 1, 1996·Pulmonary Pharmacology·L ParvezT G Rajagopalan
Jul 1, 1997·European Journal of Epidemiology·R E DalesE McMullen
Nov 14, 1997·The American Journal of Cardiology·W ZarebaM Andrews
Sep 2, 1998·The Journal of Allergy and Clinical Immunology·S R Knowles, E Weber
Apr 2, 1999·Archives of Family Medicine·J W Cranston, R Yoast
Nov 5, 1999·Biological & Pharmaceutical Bulletin·K SaitouC Kamei
Feb 29, 2000·Archives of Family Medicine·R B McFeeT R Caraccio
Oct 14, 2000·Archives of Family Medicine·W C NoonanD M Feeney
Oct 25, 2000·The Journal of Pharmacy and Pharmacology· Lee PCLR Eccles
Feb 24, 2001·Human & Experimental Toxicology·D RadovanovicH Kupferschmidt
Jul 5, 2001·Pediatric Emergency Care·S J Nairn, J E Díaz
Sep 5, 2001·Pediatrics·V L GunnJ R Serwint
Nov 1, 2001·The Cochrane Database of Systematic Reviews·K Schroeder, T Fahey

❮ Previous
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Citations

May 9, 2007·Pharmacy World & Science : PWS·Ingunn BjörnsdóttirRannveig Alma Einarsdóttir
May 10, 2005·Respiratory Physiology & Neurobiology·John Widdicombe, Vijay Singh
Jul 14, 2010·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Mahmood Noori ShadkamMohammad Reza Mozayan
Dec 13, 2005·Pediatric Emergency Care·Kevin C Osterhoudt
Dec 1, 2009·Journal of Paediatrics and Child Health·Misel TrajanovskaLinda Johnston
Jul 6, 2010·Journal of Paediatrics and Child Health·Geoffrey K IsbisterHenry A Kilham
Nov 8, 2005·Cough·Anne B Chang
Oct 12, 2011·Cough·Francesco De BlasioLuigi Lanata
Mar 30, 2011·Therapeutics and Clinical Risk Management·Maria Antonietta Catania, Salvatore Cuzzocrea
Mar 1, 2008·South African Family Practice : Official Journal of the South African Academy of Family Practice/Primary Care·Mf CottonH Rabie
Dec 17, 2009·Expert Opinion on Drug Safety·Zdravko P VassilevRaul Villa
Feb 11, 2015·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·F Lee CantrellMariam Qozi
Feb 24, 2010·The Journal of Pediatrics·Alan B Goldsobel, Bradley E Chipps
Jul 21, 2009·Annals of Emergency Medicine·Richard F ClarkDavid A Tanen
Jul 4, 2007·Journal of Pediatric Health Care : Official Publication of National Association of Pediatric Nurse Associates & Practitioners·Kerri A Irwin
Mar 14, 2016·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·G VentajaJ-M Boivin
Feb 8, 2011·Journal for Specialists in Pediatric Nursing : JSPN·Kathryn KinyonMunch
May 14, 2011·British Journal of Clinical Pharmacology·E Fatma SenUNKNOWN TEDDY European Network of Excellence
Jun 27, 2006·Paediatric Respiratory Reviews·Louis I Landau
Dec 6, 2005·Respiratory Physiology & Neurobiology·Ronald Eccles
Sep 10, 2014·Allergologia et immunopathologia·S Miceli SopoUNKNOWN Milk Honey Study (M&HS) Group
May 18, 2016·Revista paulista de pediatria : orgão oficial da Sociedade de Pediatria de São Paulo·Décio Medeiros PeixotoEmanuel Sarinho
Jul 3, 2015·Pediatrics in Review·Jennifer A Lowry, J Steven Leeder
Dec 3, 2014·The Journal of Allergy and Clinical Immunology·Sophie Anderson-JamesAnne B Chang
Jun 13, 2006·Complementary Therapies in Medicine·Bassem-Roberto SaabRamzi Sabra
Feb 8, 2011·Research in Developmental Disabilities·Jill A Hollway, Michael G Aman
Oct 14, 2004·The Annals of Pharmacotherapy·Varsha Bhatt-Mehta
Apr 25, 2017·Pediatric Pulmonology·Patricia KrummrichMichael Rubin
Jul 14, 2016·The Cochrane Database of Systematic Reviews·Samantha J GardinerHelen L Petsky
Apr 17, 2009·The Cochrane Database of Systematic Reviews·Selamawit Mulholland, Anne B Chang
Mar 29, 2014·Pharmacological Reviews·P V DicpinigaitisC P Page
Nov 25, 2014·The Cochrane Database of Systematic Reviews·Susan M SmithTom Fahey
Sep 12, 2020·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·George Sam WangRichard C Dart
Nov 17, 2010·Respiration; International Review of Thoracic Diseases·Sophie LeconteJan Degryse
May 25, 2016·Expert Review of Anti-infective Therapy·Carl Llor, Lars Bjerrum
Jul 19, 2016·Paediatrics & Child Health·Sarah J Barker

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