PMID: 9437719Jan 1, 1997Paper

Effect of diabetes mellitus on the permeability of the blood-brain barrier to insulin

Peptides
William A BanksA J Kastin

Abstract

Insulin derived from the peripheral circulation has been shown to exert various effects on the brain due to its ability to cross the blood-brain barrier (BBB). The relation between diabetes mellitus and insulin has been extensively studied for peripheral tissues but not for central nervous system tissues. We examined the effects that streptozotocin- or alloxan-induced diabetes have on the transport of insulin across the murine BBB. We used multiple-time regression analysis to measure the unidirectional influx rate constant (Ki) and vascular association (Vi) of intravenously injected, radioactively labeled human insulin (I-Ins). Treatment with streptozotocin induced an enhancement of both the Ki and Vi of I-Ins that correlated with the onset of diabetes. Brain perfusion showed that the enhanced uptake was not due to altered vascular space or levels of insulin in the serum. Alloxan enhanced Ki and Vi after 5 days but the early phase of diabetes was associated with a decreased Ki. Hyperglycemia induced by the intraperitoneal injection of glucose elevated the Vi but abolished the Ki. Furthermore, altered I-Ins uptake by brain was not associated with changes in brain or body weight. These results show that there is an increased upta...Continue Reading

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Citations

Sep 8, 2012·Molecular Neurobiology·Rasoul GhasemiAbolhassan Ahmadiani
Jul 11, 2001·Neuroscience and Biobehavioral Reviews·C R Park
Jun 6, 2000·Advanced Drug Delivery Reviews·W Pan, A J Kastin
Sep 28, 1999·Peptides·W Pan, A J Kastin
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Jul 27, 2012·Chemical Senses·Brigitte Palouzier-PaulignanDebra Ann Fadool
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Mar 22, 2014·Neuroscience Bulletin·Yanxing ChenCheng-Xin Gong
May 31, 2014·Physiology & Behavior·Joanna H SliwowskaMichael N Lehman
Jul 24, 2012·Pharmacology & Therapeutics·William A BanksMichelle A Erickson
May 6, 2015·Peptides·Thomas P DavisRichard D Egleton
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Apr 20, 2004·European Journal of Pharmacology·William A Banks
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Aug 15, 2006·Physiology & Behavior·William A Banks
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Nov 3, 2009·Biochimica Et Biophysica Acta·William A Banks
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Aug 7, 2004·Brain Research. Brain Research Reviews·Weihong Pan, Abba J Kastin
Sep 28, 2010·Peptides·William A BanksArshag D Mooradian
Oct 13, 2016·The Journal of Pharmacology and Experimental Therapeutics·Therese S SalamehWilliam A Banks
Sep 16, 2016·Journal of Neuroendocrinology·A Kleinridders
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Feb 25, 2015·Diabetes/metabolism Research and Reviews·Daniel LazardKonstantin Bloch
Jul 26, 2018·The Journal of Physiology·Elizabeth M RheaWilliam A Banks

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