Effect of diagnosis on survival benefit of lung transplantation for end-stage lung disease

Lancet
J D HosenpudR J Novick

Abstract

Although certain forms of end-stage lung disease are debilitating, whether the associated mortality rate exceeds that of transplantation is unclear. We undertook analysis to clarify the survival benefit of lung transplantation for various types of end-stage lung disease. We analysed data for all patients listed for transplantation in the USA for emphysema, cystic fibrosis, or interstitial pulmonary fibrosis in the years 1992-94. The numbers of patients entered on the waiting list, post-transplantation, died waiting, and currently waiting were: emphysema group 1274, 843, 143, and 165; cystic fibrosis group 664, 318, 193, and 59; interstitial pulmonary fibrosis group 481, 230, 160, and 48. A time-dependent non-proportional hazard analysis was used to assess the risk of mortality after transplantation relative to that for patients on the waiting list. The clearest survival benefit from lung transplantation occurred in the cystic fibrosis group. The relative risks of transplantation compared with waiting were 0.87, 0.61, and 0.61 at 1 month, 6 months, and 1 year (p = 0.008), respectively. For interstitial pulmonary fibrosis, the corresponding relative risks were 2.09, 0.71, and 0.67 (p = 0.09). No survival benefit was apparent in t...Continue Reading

References

Sep 1, 1984·In Practice·J Cox
Jun 1, 1995·The Annals of Thoracic Surgery·M ZenatiB P Griffith
Jan 1, 1995·The Journal of Thoracic and Cardiovascular Surgery·J D CooperC L Roper
Sep 15, 1993·JAMA : the Journal of the American Medical Association·F K PortK Jiang
Apr 1, 1996·American Journal of Respiratory and Critical Care Medicine·J D Cooper, S S Lefrak
Apr 1, 1996·American Journal of Respiratory and Critical Care Medicine·B J Make, A M Fein
Aug 1, 1996·The Annals of Thoracic Surgery·K S Naunheim, M K Ferguson

❮ Previous
Next ❯

Citations

Dec 26, 2001·JAMA : the Journal of the American Medical Association·T G LiouB C Marshall
Oct 14, 2004·Der Internist·J GottliebJ Niedermeyer
Sep 7, 2005·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Helen-Maria VasiliadisCharles Poirier
Sep 7, 2005·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·T P M WhelanP S Dahlberg
Jul 9, 2013·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·E V BelliJ Odell
Sep 14, 2013·Medicina clínica·Cristina BerasteguiAntonio Roman
Aug 21, 2003·The Journal of Thoracic and Cardiovascular Surgery·Gabriel ThabutMichel Fournier
Oct 3, 2003·Lancet·P M A Calverley, Paul Walker
Apr 18, 1998·Lancet·J BroekroelofsP E de Jong
Jun 27, 2003·Journal of Cardiothoracic and Vascular Anesthesia·Katherine P Grichnik, Steven E Hill
Sep 29, 2000·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·R N PiersonE W Ely
Dec 22, 2000·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·D K CooperUNKNOWN Xenotransplantation Advisory Committee of the International Society for Heart and Lung Transplantation
May 10, 2001·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·J De MeesterA Haverich
Nov 13, 2001·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·K M BeehR Buhl
Feb 9, 2002·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Susan C CharmanJohn Wallwork
Feb 9, 2002·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Michael L StanchinaLeo C Ginns
Apr 3, 2002·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Jonathan W HaftRobert H Bartlett
Mar 19, 2002·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Yussef HaiderJim J Egan
Jul 9, 2002·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·J P OuwensUNKNOWN National Steering Group for Lung Transplantation
Feb 13, 2003·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Mario C DengJames B Young
Jul 23, 2003·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Anthony De SoyzaPaul A Corris
Jul 8, 1999·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·J De MeesterA Haverich
Feb 24, 2001·Journal of the American College of Surgeons·J B Piper
Oct 1, 2005·Archivos de bronconeumología·J PadillaE Blasco
May 25, 2010·Seminars in Respiratory and Critical Care Medicine·Jamie L Todd, Scott M Palmer
Apr 8, 1999·The New England Journal of Medicine·S M Arcasoy, R M Kotloff
Jun 25, 2004·The New England Journal of Medicine·E Rand Sutherland, Reuben M Cherniack
Jan 6, 2012·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Nilto C De OliveiraKeith C Meyer
Mar 21, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·David van DellenAfshin Tavakoli
Sep 24, 1999·Annals of Surgery·B F MeyersG A Patterson
Dec 12, 2001·Transplantation·D L DeMeo, L C Ginns
Nov 26, 1999·Current Opinion in Pulmonary Medicine·B J ShapiroR G Barbers
Mar 31, 2000·Current Opinion in Pulmonary Medicine·K C MeyerR B Love
Dec 2, 2000·Current Opinion in Pulmonary Medicine·J R Yankaskas, R Aris
Oct 5, 2001·Current Opinion in Pulmonary Medicine·R SulicaM L Padilla
Aug 12, 2005·Current Opinion in Pulmonary Medicine·Raed AlalawiTony N Hodges
Sep 25, 2008·Current Opinion in Pulmonary Medicine·Paul AuroraStuart Sweet
Jan 7, 2010·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Andrea MoscatelliPietro Tuo
Feb 24, 2011·Transplantation·Qing WangUNKNOWN UK Cardiothoracic Transplant Steering Group
Apr 26, 2012·Transplantation·Véronique BoussaudMarc Stern
Mar 23, 2004·Archives of Disease in Childhood·M Burch, P Aurora
Dec 12, 2001·BMJ : British Medical Journal·H A KerstjensW van Der Bij

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation
Susan C CharmanJohn Wallwork
The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation
J De MeesterA Haverich
The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation
D M MeyerJ D Hosenpud
The Journal of Thoracic and Cardiovascular Surgery
Gabriel ThabutMichel Fournier
© 2021 Meta ULC. All rights reserved