PMID: 696436Jan 1, 1978Paper

Effect of dialysable leukocytes extracts on antibody-dependent cellular cytotoxicity and lymphocyte Fc receptors

Acta Microbiologica Academiae Scientiarum Hungaricae
K NèkámG Petrányi

Abstract

Dialysable leukocyte extracts significantly inhibited the antibody-dependent cell-mediated cytotoxicity of normal human peripheral blood lymphocytes in both xenogeneic and allogenic assays. The inhibitory effect was dose-dependent. Fractions of dialysable leukocyte extracts separated on Sephadex G-25 column differed in their capacity to suppress cytotoxicity. Dialysable leukocyte extracts did not block EA-rosetting but inhibited the resynthesis of Fc receptors. Some explanations for the observed suppressive effect are discussed.

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