PMID: 6159456Aug 1, 1980Paper

Effect of dialysis on plasma and CSF tryptophan and CSF 5-hydroxyindoleacetic acid in advanced renal disease

Journal of Neurology, Neurosurgery, and Psychiatry
P A SullivanG Curzon

Abstract

Patients with uraemic encephalopathy were previously found to have low total tryptophan (bound plus free), but high free tryptophan concentrations in the plasma and high CSF tryptophan concentrations. The 5-hydroxytryptamine metabolite 5-hydroxyindoleacetic acid was also raised in the CSF. A study of the effect of dialysis treatment on these substances in chronic uraemic patients with and without dialysis dementia is described. After an episode of dialysis the patients without dialysis dementia showed increased plasma total tryptophan and decreased free tryptophan. These changes were associated with a decrease of plasma free fatty acid. The patients with dialysis dementia did not show changes in tryptophan, but plasma free fatty acid rose. CSF concentrations of 5-hydroxyindoleacetic acid fell moderately in both groups of patients on dialysis.

References

Jul 1, 1978·Journal of Neurology, Neurosurgery, and Psychiatry·P A SullivanG Curzon
Oct 29, 1977·Lancet·G UngeE Hultman
Oct 1, 1979·Neuropharmacology·J PrattC D Marsden
Oct 1, 1978·Neurology·E C Hwang, M H Van Woert
Aug 1, 1977·Clinical Pharmacology and Therapeutics·S W Boobis
Aug 7, 1978·Acta Neuropathologica·K JellingerP Kothbauer
Jan 1, 1979·Journal of Neurology, Neurosurgery, and Psychiatry·D Chadwick, A T French
Jan 22, 1976·The New England Journal of Medicine·A C AlfreyW D Kaehny
Jan 1, 1976·Journal of Neurology, Neurosurgery, and Psychiatry·S N YoungJ B Martin
May 1, 1968·The American Journal of Medicine·H R Tyler
Feb 1, 1971·The Journal of Pharmacy and Pharmacology·J B StenlakeW W Downie
Oct 1, 1974·Kidney International·A de TorrenteP Gulyassy
Nov 1, 1974·Clinical Science and Molecular Medicine·G CurzonM H Lader
Oct 20, 1972·Nature·P J Knott, G Curzon
May 17, 1974·Clinica Chimica Acta; International Journal of Clinical Chemistry·S H Dromgoole

❮ Previous
Next ❯

Citations

Jun 1, 1982·Journal of Neurology, Neurosurgery, and Psychiatry·G CurzonP A Sullivan
Sep 7, 2019·International Journal of Tryptophan Research : IJTR·Abdulla A-B Badawy, Gilles Guillemin

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.