Effect of diazepam on adenosine 3',5'-cyclic monophosphate (cAMP) plasma levels in anesthetized patients

Clinical Therapeutics
Maria D CarcelesJesús Hernández

Abstract

It has been previously demonstrated that diazepam inhibits the cyclic nucleotide phosphodiesterase type 4 isozyme (PDE4). PDE enzymes mediate the hydrolysis of the nucleotide adenosine 3',5'-cyclic monophosphate (cAMP). The aim of this study was to determine whether IV administration of diazepam affects cAMP plasma levels in anesthetized patients. In this prospective study, patients scheduled to undergo elective myocardial revascularization surgery with anesthetization with etomidate (0.3 mg/kg), fentanyl (total dose 20-25 microg/kg), and cisatracurium (150 microg/kg), supplemented with sevoflurane (2% in an oxygen/air mixture), were randomly assigned to 1 of 3 groups to receive diazepam (0.28 mg/kg IV), diazepam vehicle (alcohol and propylene glycol IV), or saline. Before the start of the surgical procedure, at 5 and 10 minutes after administration of diazepam, vehicle, or saline, blood samples were obtained for determination of the diazepam, cAMP, and catecholamine levels. Ten patients received diazepam, 10 received vehicle, and 5 received saline. The mean (SEM) arterial serum concentrations of diazepam were 2.1 (0.2) microg/mL and 1.1 (0.4) microg/mL, respectively, at 5 and 10 minutes after administration. cAMP plasma levels...Continue Reading

References

Mar 1, 1978·The British Journal of Surgery·S N MadsenA Engquist
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Mar 26, 2003·European Journal of Pharmacology·Neal J ThomasEdwin K Jackson

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Citations

Aug 10, 2010·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·William M L Neethling, Andrew J Hodge
Mar 12, 2009·AAPS PharmSciTech·Ghada Abdelbary, Rania H Fahmy
Feb 24, 2006·Anesthesia and Analgesia·María Jesús Juan-FitaJesús Hernández

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