PMID: 6103389May 17, 1980Paper

Effect of dichloromethylene diphosphonate in Paget's disease of bone and in hypercalcaemia due to primary hyperparathyroidism or malignant disease

Lancet
D L DouglasJ S Woodhead

Abstract

30 patients with disorders of calcium metabolism were treated with dichloromethylene diphosphonate (C1(2)MDP, or clodronate disodium), an inhibitor of bone resorption. 13 patients with Paget's disease of bone were given C1(2)MDP by mouth (1.6 g/day). Serum-alkaline-phosphatase and urinary hydroxyproline fell to normal or near-normal within 3-7 months, and there was a clinical improvement in all but 1 patient. C1(2)MDP (0.8-3.2 g/day) also reduced plasma-calcium and urinary calcium in 17 patients with hypercalcaemia due to primary hyperparathyroidism or secondary to malignant disease. C1(2)MDP seems to be an effective oral drug for inhibiting excessive bone resorption in man.

References

Jan 1, 1977·The Journal of Clinical Endocrinology and Metabolism·R CanfieldW Bohne
Dec 1, 1977·Annals of Internal Medicine·M R KhairiC C Johnston
May 11, 1974·Lancet·R G RussellC G Woods
Jan 1, 1974·Acta Orthopaedica Scandinavica·O L BijvoetR Feith
Mar 1, 1971·The Journal of Endocrinology·G M AddisonJ L O'Riordan
Oct 1, 1969·Clinica Chimica Acta; International Journal of Clinical Chemistry·O L BijvoetP Fourman

❮ Previous
Next ❯

Citations

Jun 1, 1995·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·H MotoieH Kawashima
Jul 1, 1995·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·D P O'DohertyJ A Kanis
Feb 1, 1996·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·S A KhanJ A Kanis
Oct 6, 1999·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·R G RussellH A Fleisch
Jul 1, 1982·Calcified Tissue International·F J van BreukelenA T van Oosterom
Jan 1, 1990·Calcified Tissue International·J P Bonjour, R Rizzoli
Dec 1, 1987·Calcified Tissue International·S AdamiV Lo Cascio
Feb 14, 2013·International Orthopaedics·Tomasz MazurkiewiczMagdalena Jaszek
Jun 6, 1998·Clinica Chimica Acta; International Journal of Clinical Chemistry·G LippiG Guidi
Jul 16, 2008·Lancet·Stuart H RalstonIan R Reid
Feb 15, 1988·Wiadomości lekarskie : organ Polskiego Towarzystwa Lekarskiego·Z Gburek, H Müller-Fassbender
Aug 6, 1981·The New England Journal of Medicine·A JungS Rosini
Jun 23, 1983·The New England Journal of Medicine·A JungM E Kitler
Apr 30, 1992·The New England Journal of Medicine·J P Bilezikian
Jul 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·G MilhaudY Moricard
Jul 1, 1992·British Journal of Clinical Pharmacology·S H Ralston
Jan 1, 1985·Annals of the Rheumatic Diseases·P DewisS Willets
Feb 19, 1983·British Medical Journal·D L DouglasR G Russell
Mar 17, 1984·British Medical Journal·R Wilkinson
Oct 27, 1984·British Medical Journal·A J YatesJ A Kanis
Feb 1, 1987·Postgraduate Medical Journal·P Altmann, J Cunningham
Oct 1, 1981·The Journal of Clinical Investigation·P MinaireG Pilonchery
Dec 1, 1991·The Journal of Clinical Investigation·M SatoG A Rodan
Jul 7, 1999·Journal of Clinical Pharmacology·D L Brown, R Robbins
Oct 23, 1997·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·S A KhanA G Porras
Oct 16, 2004·Journal of Clinical Pharmacy and Therapeutics·E CauzaA Dunky
Jul 13, 2006·Annals of the New York Academy of Sciences·R Graham G Russell
Apr 1, 1989·Scandinavian Journal of Dental Research·M CaracatsanisL Hammarström
Feb 23, 1987·The American Journal of Medicine·F R Singer, M Fernandez

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.